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MYD88 — TNF

Text-mined interactions from Literome

Underhill et al., Proc Natl Acad Sci U S A 1999 : Expression of a dominant negative form of MyD88 ( a signaling component required for toll-like receptor signaling ) in a mouse macrophage cell line blocks TNF-alpha production induced by M. tuberculosis
Means et al., J Immunol 2001 (Tuberculosis) : Lastly, we demonstrated that a dominant negative MyD88 mutant could block Mtb induced activation of the TNF-alpha promoter, but not the inducible NO synthase promoter, in murine macrophages
Wang et al., Br J Haematol 2002 (Granuloma...) : MyD88 is involved in the signalling pathway for Taxol induced apoptosis and TNF-alpha expression in human myelomonocytic cells
Seki et al., J Immunol 2002 (Inflammation...) : Furthermore, MyD88-deficient, but not IFN-gamma-deficient, Kupffer cells could not produce TNF-alpha in response to LM in vitro, indicating the importance of MyD88 dependent TNF-alpha production for host defense ... These results indicated a critical role for TLRs/MyD88 dependent IL-12/TNF-alpha production and for IL-12- and IL-18 mediated IFN-gamma production in early phase clearance of LM
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Huang et al., J Immunol 2003 : Our results show that HKBA mediated induction of IL-12p40 and TNF is dependent on the adapter molecule MyD88
Andreakos et al., Blood 2004 : In contrast, in macrophages neither MyD88 , Mal/TIRAP, nor I kappa B kinase 2 (IKK2) are required for NF-kappa B activation or tumor necrosis factor alpha (TNF alpha) , IL-6, or IL-8 production, although Mal/TIRAP is still involved in the production of interferon beta (IFN beta)
Yan et al., Infect Immun 2004 : Role of MyD88 in diminished tumor necrosis factor alpha production by newborn mononuclear cells in response to lipopolysaccharide
Sun et al., Nat Immunol 2006 : Here we demonstrate that MyD88 increased the half-life but not the synthesis of IFN-gamma induced mRNA transcripts encoding tumor necrosis factor and IFN-gamma-inducible protein 10
Matikainen et al., J Virol 2006 : IFN-alpha and TNF-alpha induced the expression of the RIG-I, TLR3, MyD88 , TRIF, and IRF7 genes, whereas no detectable TLR7 and TLR8 was seen in A549 cells
Esen et al., J Immunol 2006 : The induction of TNF-alpha , IL-12 p40, and MIP-2 ( CXCL2 ) expression by S. aureus- and peptidoglycan stimulated microglia was MyD88 dependent , as revealed by the complete inhibition of cytokine production in MyD88 KO cells
Skerrett et al., Am J Physiol Lung Cell Mol Physiol 2007 (Lung Diseases...) : TNF induction required MyD88 and was absent in TLR2/4 ( -/- ) cells in response to fliC but not wild-type P. aeruginosa, whereas TLR2 ( -/- ) cells exhibited augmented responses
Sacre et al., Am J Pathol 2007 (Arthritis, Rheumatoid...) : In addition, overexpression of dominant negative forms of MyD88 and Mal/TIRAP significantly down-regulated the spontaneous production of cytokines tumor necrosis factor-alpha , IL-6, and vascular endothelial growth factor, and enzymes MMP-1, MMP-2, MMP-3, and MMP-13 in RA synovial membrane cell cultures
West et al., BMC immunology 2008 (Liver Abscess...) : TLR adaptor molecule MyD88 strongly regulated TNF-alpha production in response to heat killed B. pseudomallei
Durães et al., Immunol Lett 2009 : IL-12 and TNF-alpha production by dendritic cells stimulated with Schistosoma mansoni schistosomula tegument is TLR4- and MyD88 dependent
Abbas et al., Free Radic Biol Med 2009 : Moreover, addition of exogenous TNF allowed the recovery of full PRX5 expression in both MyD88 ( -/- ) and TNF ( -/- ) cells stimulated with IFN-gamma, suggesting that basal TNF produced in an MyD88 dependent manner contributes to PRX5 induction
Siegemund et al., J Virol 2009 : In contrast, iPPVO induced TNF-alpha release and enhanced expression of MHC-I and CD86 but not of MHC-II by BMDC chiefly requires MyD88 but not TLR2 or TLR4
Griffith et al., J Immunol 2009 (Inflammation...) : In macrophages prestimulated with IFN-gamma, sHz also results in a MyD88 dependent release of TNF-alpha
West et al., Infect Immun 2009 (Burkholderia Infections...) : In macrophages, TLR4 and the adaptor molecule MyD88 , but not TLR2 or TLR5, are required for tumor necrosis factor alpha production induced by B. thailandensis
Langlet et al., Eur J Immunol 2010 : Unexpectedly, BM-derived DC from PKC-alpha ( -/- ) mice exhibited decreased TNF-alpha and IL-12p40 production induced by both MyD88- and TRIF dependent ligands
Loof et al., Am J Pathol 2010 (Genetic Predisposition to Disease...) : Absence of MyD88 resulted in diminished production of inflammatory cytokines such as interleukin-12, interferon-gamma, and tumor necrosis factor-alpha as well as chemoattractants such as monocyte chemotactic protein-1 (MCP-1) and Keratinocyte derived chemokine ( KC ), and hampered recruitment of effector cells involved in bacterial clearance ( macrophages and neutrophils ) to the infection site
Downes et al., Immunology 2010 (Bacterial Infections...) : Signalling pathways triggered by TLR4 and TLR9 involve MyD88 and are partially mediated by the cytokine tumour necrosis factor-a (TNF-a)
Kissner et al., Innate Immun 2011 (Disease Models, Animal...) : Our results indicated that elevated tumor necrosis factor-a , interferon-?, interleukin (IL)-1a/ß and IL-6 production from mouse spleen cells treated with SEB alone or in combination with lipopolysaccharide (LPS) was regulated by MyD88
Sokolove et al., Arthritis Rheum 2011 (Arthritis, Rheumatoid...) : Stimulation of TNF by cFb was dependent on TLR-4 and MyD88 , while stimulation by cFb-IC was dependent on both TLR-4/MyD88 and Fc?R
Kar et al., Eur J Immunol 2011 (Inflammation...) : Analysis of upstream signaling events revealed that TLR 2/4 mediated MyD88 dependent participation of IL-1R activated kinase (IRAK)1, TNF receptor associated factor (TRAF)6 and TGFß activated kinase (TAK)1 is essential to induce cystatin mediated I?B kinase ( IKK ) /NF-?B activation in macrophages
Siednienko et al., J Immunol 2011 : Although MyD88 does not significantly affect TLR3 ligand induced TNF-a induction, MyD88 negatively regulates TLR3-, but not TLR4-, mediated IFN-ß and RANTES production ; this process is mechanistically distinct from that employed by Mal/TIRAP
Li et al., J Immunol 2011 (HIV Infections...) : Targeted gene silencing of MyD88 ( short hairpin RNA ) and mTOR ( RNA interference ) inhibition resulted in TLR-4 mediated 70-kDa ribosomal protein S6 kinase activation and enhanced TNF-a release, whereas IL-10 release was inhibited in both silenced and nonsilenced HIV ( + ) macrophages
Guerrero et al., Eur J Pharmacol 2012 : Moreover, the joint production of TNF-a , IL-1ß and CXCL1/KC by zymosan was dependent on TLR2/MyD88 signaling
Delpino et al., J Leukoc Biol 2012 (Brucellosis) : Macrophage elicited osteoclastogenesis in response to Brucella abortus infection requires TLR2/MyD88 dependent TNF-a production
Fortes et al., Blood 2012 (Necrosis) : Heme induced cell death required TNFR1 and TLR4/MyD88 dependent TNF production
Kim et al., Immunology 2012 (MAP Kinase Signaling System) : Rv0652 stimulated TNF and MCP-1 secretion by macrophages occurred in a Toll-like receptor 4-dependent and MyD88 dependent manner
Majumder et al., Curr Top Med Chem 2012 : Additionally, myeloid differentiation factor 88 ( MyD88 ), an adapter protein regulates the expression of TNF under thalidomide treatment
Klaas et al., J Immunol 2012 : This was accompanied by a strong reduction in MyD88 dependent secretion of TNF-a , IL-6, IL-12, and IL-10
Liu et al., J Neurosci 2013 : In cultured neurons, TLR7 activation induced IL-6 and TNF-a expression through Myd88
Gao et al., Fish Shellfish Immunol 2013 : Moreover, the inhibitor of homodimerization of myeloid differentiation factor 88 ( MyD88 ) could significantly reduce the up-regulation of TLR21, MyD88, and tumor necrosis factor (TNF) expression in CpG ODN or poly I:C treated head kidney cells in vitro
Wesche et al., Immunity 1997 : Thus, MyD88 plays the same role in IL-1 signaling as TRADD and Tube do in TNF and Toll pathways, respectively : it couples a serine/threonine protein kinase to the receptor complex