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IL6 — LTA

Text-mined interactions from Literome

Scott et al., Infect Immun 1999 : This correlated with the ability of the peptides to block LTA induced production of TNF and interleukin-6 by RAW 264.7 cells but did not correlate with their ability to kill the bacteria
Wang et al., Infect Immun 2000 : We have examined the ability of peptidoglycan ( PepG ) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) , and IL-10 in whole human blood and identified the cellular origins of these cytokines ... LTA , as well as lipopolysaccharide, induced IL-6 and IL-10 mRNA production in monocytes and possibly in T cells
Morath et al., Infect Immun 2002 : After purification, the commercial LTA from Bacillus subtilis and S. pyogenes but not LTA from S. aureus induced the release of tumor necrosis factor alpha, interleukin 1 beta (IL-1beta), IL-6, and IL-10 in human blood
Hermann et al., Eur J Immunol 2002 : All LTA induced the release of TNF-alpha, IL-1beta, IL-6 and IL-10 in human whole blood
Nasu et al., Fertil Steril 2003 : The effects of IL-13 and TNF-beta , on the production of IL-6 , IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene alpha ( GROalpha ), monocyte chemoattractant protein-1 ( MCP-1 ), regulated on activation, T-cell expressed and secreted ( RANTES ), and eotaxin were investigated
Moesby et al., Eur J Pharm Sci 2003 : Lipoteichoic acid (LTA) isolated from B. subtilis induces interleukin-6 in a dose dependent manner, whereas muramyl dipeptide ( MDP ) is unable to induce interleukin-6 ... The interleukin-6 secretion induced by LPS, LTA and B. subtilis bacteria can be blocked by 73-85 % by an antibody directed against CD14, whereas the antibody only blocks 25 % of B. subtilis endospores induced interleukin-6 release
Walker et al., J Immunol 1992 (Mycobacterium Infections) : In particular, IL-1 (-alpha and -beta), IL-2, TNF (-alpha and -beta) , and IFN-gamma mRNA were readily detected , whereas IL-3, IL-4, IL-5, IL-6 , IL-7, and granulocyte-macrophage colony stimulating factor mRNA were not detected, or were detectable only at very low levels
Dahle et al., Infect Immun 2004 : In the present study, we have started to assess the signal transduction events by which LTA induces the production of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) , and the anti-inflammatory cytokine IL-10 in rat Kupffer cells
Hasty et al., J Immunol 2006 : However, Streptococcus pyogenes LTA essentially devoid of D-alanine caused human and mouse cells to secrete as much IL-6 as LTA with a much higher D-alanine content
Fabisiak et al., Am J Physiol Lung Cell Mol Physiol 2006 (Lung Diseases...) : Preexposure to TNF-beta sensitized the cells to subsequent MALP-2 challenge, but preexposure to MALP-2 did not alter the IL-6 response to TNF-beta
Liu et al., J Am Soc Nephrol 2006 (Cardiovascular Diseases) : TNF-beta that is encoded by lymphotoxin-alpha gene (LTA) regulates adhesion molecules and IL-6
Talreja et al., Inflammation 2005 : Incubation of Chang cells with LPS ( 1 to 1,000 ng/ml ) failed to stimulate IL-6 production where as stimulation with LTA or PGN resulted in marked increases in IL-6 production
Zhao et al., Immunol Lett 2007 (Fever) : Pretreatment of mice with 39.5 degrees C temperature also enhanced LPS, but not LTA , induced TNF-alpha and IL-6 production in vivo
Cox et al., Infect Immun 2007 : The first results in a slight enhancement of IL-6 secretion in response to LTA plus Hb compared to that with LTA alone and is TLR4 independent
Chan et al., Infect Immun 2007 (Streptococcal Infections) : LTA purified from the bacteria induced tumor necrosis factor-alpha and IL-6 production from wild-type DCs but not from TLR2 knockout DCs, and the mutant LTA induced a significantly smaller amount of these two cytokines
Galatowicz et al., Clin Exp Allergy 2007 (Conjunctivitis, Allergic...) : For conjunctival biopsy derived cultures ( n=11 ), FcepsilonR1 stimulation increased histamine, TNF-alpha, TNF-beta , IL-5 and IL-8 levels and the production of IL-5, IL-6 ( P < 0.05 ), histamine and IL-8 ( P < 0.01 ) was inhibited by epinastine
Jana et al., Immunology 2009 : Induction of lymphotoxin-alpha by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
Bayraktar et al., Am J Reprod Immunol 2009 : IL-6 and IL-8 were induced to comparable levels in response to both LTA and LPS whereas monocyte chemotactic protein-1 (MCP-1) production was induced more by LTA , demonstrating a differential placental response to a specific toll-like receptor ( TLR ) ligand
Chang et al., Shock 2010 : Exposure of macrophages to a therapeutic concentration of ketamine ( 100 microM ) inhibited LTA induced TNF-alpha and IL-6 expressions at protein or mRNA levels
Lee et al., Am J Pathol 2010 (Inflammation) : In this study, LTA induced cPLA(2) and COX-2 expression and PGE ( 2 ) or IL-6 synthesis were attenuated by transfection with siRNAs of TLR2, MyD88, Akt, p42, p38, JNK2, and p65 or pretreatment with the inhibitors of PI3K ( LY294002 ), p38 ( SB202190 ), MEK1/2 ( U0126 ), JNK1/2 ( SP600125 ), and NF-kappaB ( helenalin ) in human tracheal smooth muscle cells ( HTSMCs ) ... LTA regulated PGE ( 2 ) or IL-6 production was inhibited by pretreatment with the inhibitors of cPLA(2) ( AACOCF ( 3 ) ) and COX-2 ( NS-398 ) or transfection with cPLA(2) siRNA or COX-2 siRNA, respectively
Declue et al., Vet J 2012 (Inflammation) : LPS, LTA and PG stimulated tumor necrosis factor (TNF) and interleukin (IL)-6 production but only LTA and PG stimulated IL-1ß production from whole blood ... LPS was a more potent inducer of TNF than either LTA or PG and both LPS and LTA were more potent inducers of IL-6 than PG
Jeon et al., Comp Immunol Microbiol Infect Dis 2012 : Here, we showed that staphylococcal LTA ( Sa.LTA ) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator ( phorbol 12-myristrate 13-acetate ; PMA ), and a calcium ionophore ( A23187 ), whereas Sa.LTA alone could not induce IL-6 expression
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA , but no other TLR2 ligands ... Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6) , and IL-10 in response to S. aureus or LTA , but no other TLR2 ligands
Palladino et al., Ciba Found Symp 1987 (Neoplasms, Experimental) : Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or TNF-beta may involve the following biological activities : the induction of interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Sugiyama et al., Infect Immun 1996 : In contrast, LPS induced interleukin 1 activity in human gingival epithelial cells in culture, while LTA had little effect
Vallejo et al., J Infect Dis 1996 (Streptococcal Infections) : GBS III-PS, GB-Ag, and LTA each induced IL-6
Goldbach et al., Eur J Pharmacol 1997 : Thereafter interleukin-6 and cortisol declined again in response to TNF-beta , but further increased after infusion with TNF-alpha to peak values measured 3 h after the start of infusion ( interleukin-6 : 258 +/- 52 I.U./ml ; cortisol : 790 +/- 167 ng/ml )
Worm et al., Immunology 1998 (Hypersensitivity) : Stimulation of human B cells with anti-CD40 + interleukin-4 ( IL-4 ) results not only in proliferation and immunoglobulin E ( IgE ) -production, but also increased production of the cytokine lymphotoxin-alpha (LT-alpha) ( formerly also known as tumour necrosis factor-beta (TNF-beta) )