◀ Back to PTGS2
MAP2K1 — PTGS2
Text-mined interactions from Literome
Yan et al., J Biol Chem 2000
:
B [ a ] P caused a rapid increase in phosphorylation of extracellular signal regulated kinase ( ERK ) ; pharmacologic inhibition of
mitogen activated protein kinase kinase blocked B [ a ] P-mediated induction of
COX-2
Kulkarni et al., Clin Cancer Res 2001
(Adenocarcinoma...) :
The induction of
COX-2 by EGF was
suppressed by inhibitors of tyrosine kinase activity, phosphatidylinositol 3-kinase,
mitogen activated protein kinase kinase , and p38 mitogen activated protein kinase
Marrache et al., J Immunol 2002
:
COX-2 expression was
prevented by
mitogen activated protein kinase kinase/extracellular signal regulated kinase 1/2 and NF-kappaB inhibitors
Jiang et al., J Biol Chem 2004
:
Either PD98059 or U0126, selective inhibitors of MEK, or overexpression of a dominant negative
MEK-1 inhibited interleukin-1beta-
induced ERK activation and the expression of iNOS and
COX-2 but had essentially no effect on the expression of VCAM-1 and Mn-SOD
Johnson et al., J Exp Ther Oncol 2004
(Carcinoma, Squamous Cell...) :
COX-2 induction by imatinib was
blocked by
MEK1 or EGF receptor inhibition
Lim et al., FEBS Lett 2005
:
The p38 MAPK inhibitor, SB203580, or
MEK1/2 inhibitor, U0126,
inhibited hypertonic induction of
COX-2 expression
Liu et al., Am J Respir Cell Mol Biol 2007
:
EGF receptor (EGFR) inhibition, neutralizing antibody against amphiregulin, or
mitogen activated protein kinase kinase ( MEK ) inhibition
blocked TGF-beta1 mediated
COX-2 induction
Hsieh et al., Biochim Biophys Acta 2008
:
Moreover, thrombin stimulated
activation of NF-kappaB, AP-1, and
COX-2 promoter activity was blocked by the inhibitors of c-Src, PKC, EGFR,
MEK1/2 , AP-1 and NF-kappaB, suggesting that thrombin induces COX-2 promoter activity mediated through PKC ( delta ) /c-Src dependent EGFR transactivation, MEK-ERK1/2, AP-1, and NF-kappaB
Zhang et al., Mol Cancer Res 2008
(Carcinoma, Squamous Cell...) :
In HNSCC cells, the bradykinin induced expression of
COX-2 was
inhibited by the EGFR kinase inhibitor gefitinib or
mitogen activated protein kinase kinase inhibitors ( PD98059 or U0126 )
Kang et al., Cancer prevention research (Philadelphia, Pa.) 2008
(Cell Transformation, Neoplastic) :
Here, we report that delphinidin, a major dietary anthocyanidin,
inhibits tumor promoter induced transformation and
cyclooxygenase-2 (COX-2) expression in JB6 promotion-sensitive mouse skin epidermal ( JB6 P+ ) cells by directly targeting Raf and
mitogen activated protein kinase kinase ( MEK )
Chen et al., Chem Res Toxicol 2012
(MAP Kinase Signaling System...) :
Overexpression of the upstream ERK activator
MEK1 significantly and consistently
increased 2-ABP mediated
COX-2 expression