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GAB2 — MAPK4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Liu et al., Mol Cell Biol 2001
:
Overexpression of
Gab2 in FD-Fms cells
enhanced both
mitogen activated protein kinase ( MAPK ) activity and macrophage differentiation, but reduced proliferation, in response to M-CSF
Million et al., Mol Cell Biol 2004
(Cell Transformation, Neoplastic...) :
A Tel-Abl point mutant ( Y314F ) and a splice variant without TEL exon 5 sequences ( Deltae5 ) lacked Grb2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein
Gab2 and impaired
activation of phosphatidylinositol 3-kinase, Akt, and extracellular signal regulated
kinase/mitogen activated protein kinase in hematopoietic cells
Zhang et al., Mol Cell Biol 2013
(Breast Neoplasms) :
We now demonstrate that activation of the Ras/mitogen activated protein kinase (
MAPK ) pathway
promotes Gab2 phosphorylation on basic consensus motifs