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E2F1 — TK1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database E2F transcription factor network:
E2F1/DP complex (E2F1-TFDP2_TFDP1)
→
TK1 (TK1)
(transcription, activates)
Wu et al., Nature 2001, Li et al., Mol Cell Biol 1994, Karlseder et al., Mol Cell Biol 1996, Cartwright et al., Oncogene 1998
Evidence: mutant phenotype, reporter gene, physical interaction, other species
Text-mined interactions from Literome
Ogris et al., J Virol 1993
:
A binding site for transcription factor
E2F is a
target for trans activation of murine
thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene
Hengstschläger et al., Oncogene 1996
(Precursor Cell Lymphoblastic Leukemia-Lymphoma) :
The role of p16 in the
E2F dependent
thymidine kinase regulation ... Phosphorylation of the retinoblastoma protein by cyclin dependent kinases 4 and 6 prevents its interaction with the transcription factor
E2F , which subsequently
promotes the expression of S phase regulated genes, such as
thymidine kinase