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GAD2 — IL1B

Text-mined interactions from Literome

Hao et al., Autoimmunity 1999 (Diabetes Mellitus, Type 1) : In this study we investigated the role of the NO pathway in mediating the effects of IL-1beta on GAD-65 and HSP-70 expression and on insulin secretion ... Our findings indicate that the effect of IL-1beta on HSP-70 expression is mediated by NO production, whereas a NO-independent pathway is involved in the effect of IL-1beta on GAD-65 expression and insulin secretion
Hao et al., J Interferon Cytokine Res 1995 : ( 3 ) In combination, TGF-beta at 1, 10, and 40 ng/ml did not antagonize the IL-1 beta ( 50 and 100 pg/ml ) -induced inhibition of insulin secretion or cytotoxicity ; TGF-beta ( 40 ng/ml ) did not block the effects of IL-1 beta ( 1000 pg/ml ) on HSP-70 or GAD-65 expression
Hao et al., Autoimmunity 1995 : In summary : 1 ) IL-1 beta dramatically inhibits GAD-65 expression