Gene interactions and pathways from curated databases and text-mining

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IL1B — IRAK2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: IRAK2 → IL1B (increases)
    Evidence: The mRNA expression data of IRAK-2 closely correlated with the IRAK-2 protein levels as determined by Western blotting (Fig. 10). (For last two evidence lines)
  • BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  • BioCarta signal transduction through il1r: IRAKs (IRAK3/IRAK1/IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
  • BioCarta signal transduction through il1r: TOLLIP → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  • BioCarta signal transduction through il1r: MYD88 → IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) (modification, collaborate)
  • BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1RAcP (IL1RAP) (modification, collaborate)
  • BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1-beta (IL1B) (modification, collaborate)
  • BioCarta signal transduction through il1r: IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2) → IL-1R (IL1R1) (modification, collaborate)

Text-mined interactions from Literome

Wan et al., Cell Signal 2001 : However, IL-1beta induced IRAK activation was not affected by PD153035
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : However, neither TNF-alpha nor IL-1beta induced IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
Russo et al., Cell Signal 2004 : Despite similar 125I-IL-1beta binding, HT-29 cells displayed no IRAK degradation, a 75 % reduction of IKK activity, and decreased IkappaBalpha phosphorylation, NF-kappaB DNA binding activity and IL-8 mRNA accumulation in response to IL-1beta compared to Caco-2 cells
Rutkute et al., Hepatology 2007 : These age related changes in JNK phosphorylation correlated with diminished IL-1beta induced degradation of interleukin-1 receptor associated kinase-1 ( IRAK-1 )
Ahmad et al., J Immunol 2009 : The role and relative contribution of MyD88, IRAK1 , and TRAF6 adaptor proteins in IL-1beta regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown ... By small interfering RNAs mediated knockdown, we show that IL-1beta induced up-regulation of ADAMTS-4 in chondrocytes requires MyD88, IRAK1 , and TRAF6 adaptor proteins