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IL1B — IRAK2
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
IRAK2
→
IL1B
(increases)
Evidence: The mRNA expression data of IRAK-2 closely correlated with the IRAK-2 protein levels as determined by Western blotting (Fig. 10). (For last two evidence lines)
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BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IRAKs (IRAK3/IRAK1/IRAK2)
→
IL-1-beta (IL1B)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
TOLLIP
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
MYD88
→
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1RAcP (IL1RAP)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1-beta (IL1B)
(modification, collaborate)
-
BioCarta signal transduction through il1r:
IL-1-beta/IL-1RI/IL-1RAcP/TOLLIP/MYD88/IRAKs complex (IL1B-IL1R1-IL1RAP-MYD88-TOLLIP-IRAK3_IRAK1_IRAK2)
→
IL-1R (IL1R1)
(modification, collaborate)
Text-mined interactions from Literome
Wan et al., Cell Signal 2001
:
However,
IL-1beta induced
IRAK activation was not affected by PD153035
Ferlito et al., J Leukoc Biol 2001
(Leukemia, Monocytic, Acute...) :
However, neither TNF-alpha nor
IL-1beta induced
IRAK degradation or stimulated TNF-alpha or TxB2 production in naive cells
Russo et al., Cell Signal 2004
:
Despite similar 125I-IL-1beta binding, HT-29 cells displayed no
IRAK degradation, a 75 % reduction of IKK activity, and decreased IkappaBalpha phosphorylation, NF-kappaB DNA binding activity and IL-8 mRNA accumulation in
response to
IL-1beta compared to Caco-2 cells
Rutkute et al., Hepatology 2007
:
These age related changes in JNK phosphorylation correlated with diminished
IL-1beta induced degradation of
interleukin-1 receptor associated kinase-1 ( IRAK-1 )
Ahmad et al., J Immunol 2009
:
The
role and relative contribution of MyD88,
IRAK1 , and TRAF6 adaptor proteins in
IL-1beta regulation of aggrecanase-1 ( ADAMTS-4 ) is unknown ... By small interfering RNAs mediated knockdown, we show that
IL-1beta induced up-regulation of ADAMTS-4 in chondrocytes
requires MyD88,
IRAK1 , and TRAF6 adaptor proteins