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IL1B — SERPINE1

Text-mined interactions from Literome

Seki et al., Am J Physiol 1999 (Acute-Phase Reaction...) : These results suggest that IL-1beta is a critical inducer of hepatic PAI-1 gene expression during the acute phase response to local tissue injury
Birgel et al., Arterioscler Thromb Vasc Biol 2000 : In addition, data suggest that TNF-alpha and IL-1beta also have stimulatory effects on PAI-1 protein secretion and may contribute to the elevated PAI-1 levels observed in obesity
Chung et al., J Clin Endocrinol Metab 2001 : We investigated the role of IL-1beta in regulating u-PA, PAI-1 , u-PAR, and soluble u-PAR messenger ribonucleic acid ( mRNA ) expression in cultured human endometrial stromal cells using quantitative competitive PCR ... IL-1beta increased PAI-1 , u-PAR, and soluble u-PAR expression in a dose dependent manner, and this result was reversed by anti-IL-1beta antibody treatment
He et al., Horm Metab Res 2000 : However, after 24 and 48 h, dexamethasone significantly reduced the IL-1beta induced increase in PAI-1 activity by 24-52 % ( p < 0.05 ), accordingly, PAI-1 mRNA expression was reduced 60 % ... Finally, the induction of PAI-1 activity and PAI-1 mRNA expression by IL-1beta was attenuated by estrogen ( 17.8+/-4.9 %, p < 0.05 and 20.9+/-5.8 %, p < 0.05, respectively )
Montes et al., Thromb Haemost 2002 (Disseminated Intravascular Coagulation...) : Previous findings suggest that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are responsible for the increase in the level of PAI-1 ... These results suggest that PAI-1 increase might be independent of TNF-alpha and IL-1beta
Warocquier-Clérout et al., Cytotechnology 1991 : IL-1 beta stimulated the release of PAI-1 antigen quantified by immunoassay and the kinetics of secretion were comparable on both coated and uncoated substratum
Dong et al., Hypertens Res 2003 (Acute-Phase Reaction...) : Because the liver is one of the major sources of circulating PAI-1, we here examined the effects of two proinflammatory cytokines, interleukin (IL)-1beta , and IL-6, on PAI-1 production in a human hepatoma cell line, HepG2 ... IL-1beta ( 1 ng/ml ) and IL-6 ( 1 ng/ml ) increased the accumulation of PAI-1 in the conditioned media over 24 h ( IL-1beta : 2.1 +/- 0.2 ( mean +/- SD ) fold over the control ; IL-6 : 1.4 +/- 0.2 fold ; Western blot, p < 0.05 ) ... An HMG-CoA reductase inhibitor ( mevastatin, 10 micromol/l ) attenuated the PAI-1 production induced by IL-1beta and IL-6 ... Thus, 1 ) IL-1beta and IL-6 can increase PAI-1 production in hepatic cells and 2 ) mevastatin may exert anti-thrombotic effects by decreasing the PAI-1 protein production induced by these proinflammatory cytokines
Yoshida et al., Brain Res 2006 : We have studied the effect of interleukin-1beta (IL-1beta) , one of major cytokines also active in the nervous system, on the angiotensin II-induced expression of PAI-1 in human astrocytes ... After 24-h stimulation, 10 ng/ml IL-1beta and 10 nM angiotensin II increased the levels of PAI-1 protein in astrocyte conditioned medium by 1.9-fold and 1.8-fold of the basal value, respectively
Okazaki et al., Endocr J 2008 (Inflammation...) : Interleukin 1beta and insulin also cooperatively increased the endogenous mRNA level of PAI-1
Zhu et al., Osteoarthritis Cartilage 2009 : Additionally, IL-1beta stimulated both HIF-1alpha and PAI-1 in articular chondrocytes, and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing
Hakkert et al., Blood 1990 : The effect of IL-1 beta on PAI-1 release by endothelial cells closely resembled that observed for monocytes
DiBattista et al., Mol Cell Endocrinol 1994 (Cadaver) : Our objective was to delineate the mechanisms by which PGE2 and IL-1 beta , inflammatory mediators commonly found at sites of inflammation, regulate the expression and synthesis of PAI-1 in human synoviocytes
Soeda et al., Biochim Biophys Acta 1995 : Interleukin-1 beta (IL-1 beta) is a potent inducer of PAI-1 in cultured HUVEC ... Heparin, OSF, and its fragments did not suppress the IL-1 beta induced release of PAI-1 antigen
Yamamoto et al., Biol Pharm Bull 1993 : In contrast, PAI-1 : Ag release was significantly increased by either IL-1 beta or TNF alpha ; ET-1 significantly reduced the stimulatory effect of the cytokines