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JUN — MMP2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Sato et al., Cancer Res 2002
(Fibrosarcoma...) :
These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin mediated inhibition of
activator protein-1 binding activity is at least partly
involved in the suppression of
MMP expression
Choi et al., Cancer Res 2005
(Carcinoma, Non-Small-Cell Lung...) :
Reporter assays combined with deletion mutagenesis analysis and gel shift assays showed the
involvement of
activator protein 1 in the activation of
MMP-2 promoter activity by Bcl-2
Nishiya et al., J Pharmacol Sci 2006
(Disease Models, Animal...) :
Five days after MI, EPO prevented the increase in activated caspase 3,
matrix metalloproteinase-2 , and transcriptional
activation of
activator protein-1 in non infarcted myocardium
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Hammaker et al., Arthritis Res Ther 2007
(Arthritis, Rheumatoid) :
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (
MMP ) gene expression and joint destruction in inflammatory arthritis
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Hasegawa et al., Exp Cell Res 2009
(Neoplasm Invasiveness) :
In addition, silencing of
c-Jun expression by siRNA transfection
suppressed MMP-2 and MMP-9 production and in vitro invasiveness
Jiménez et al., Biochem Biophys Res Commun 2009
:
Furthermore, Ang II-induced
MMP 2 activation was markedly blocked by SP600125, a selective
c-Jun N-terminal kinase (JNK) inhibitor, or pre-treatment of cells with antisense oligonucleotide to focal adhesion kinase ( FAK ), indicating that both molecules were important for the activation of MMP 2 by Ang II receptor stimulation
Zhang et al., J Surg Res 2009
:
AP-1 inhibits expression of
MMP-2/9 and its effects on rat smooth muscle cells
Ni et al., J Biol Chem 2010
(Hyperplasia) :
Adenovirus forced
c-Jun expression
stimulated SMC proliferation, proliferating cell nuclear antigen, and
MMP-2 expression
Liu et al., J Cell Physiol 2010
:
Knock-down of c-Fos and c-Jun by siRNA reflected that c-Fos counteracted the
effect of
c-Jun on
MMP-2/MMP-9 down-regulation
Liu et al., Clin Orthop Relat Res 2011
(Disease Models, Animal...) :
QUESTIONS/HYPOTHESIS : I hypothesize : ( 1 ) intracellular MMP-2 plays an important role during muscle atrophy by digesting intramuscular matrix ; ( 2 )
AP-1 and NFAT signal transduction pathways are
responsible for expression and activation of the intracellular
MMP-2 during muscle atrophy ; and ( 3 ) specific MMP-2 inhibitors can serve as a novel pharmacologic strategy in treating disuse induced muscle atrophy
Chan et al., International journal of molecular sciences 2011
:
In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial
membrane potential ( MMP ) changes,
activation of caspase-9, caspase-3, p21 activated protein kinase 2 (PAK2) and
c-Jun N-terminal kinase (JNK) , and gene expression of p53 and p21 involved in apoptotic signaling
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of mitogen activated protein kinase ( MAPK ), ATF-2, and
c-Jun , and
MMP expression