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MMP3 — TLR2

Text-mined interactions from Literome

Kawamura et al., Experimental biology and medicine (Maywood, N.J.) 2008 : The active form of MMP-3 induced the VEGF mRNA expression, as well as TLR2 , in adipocytes ... The enhancement of FFAs induced TLR2 expression by Mphi-CM was inhibited by blocking of the MMP-3
West et al., J Cell Biol 2008 : Surprisingly, MMP inhibitors block TLR signaling induced podosome disassembly, although stimulated endocytosis is unaffected, which demonstrates that the two phenomena are not obligatorily coupled
Ospelt et al., Arthritis Rheum 2008 (Arthritis, Rheumatoid...) : Among the expressed TLRs, TLR-3 and TLR-4 were the most abundant in synovial fibroblasts, and stimulation of synovial fibroblasts with the TLR-3 ligand poly ( I-C ) led to the most pronounced increase in IL-6, MMP-3 , and MMP-13
Liu-Bryan et al., Arthritis Rheum 2010 : TLR-2/TLR-4 ( -/- ) and MyD88 ( -/- ) mouse cartilage explants and chondrocytes lost the capacity to mount procatabolic responses to both LMW-HA and HMGB-1, demonstrated by > 95 % suppression of NO production ( P < 0.01 ), and attenuated induction of MMP-3 and MMP-13