Callery et al., Dev Biol 2010
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We demonstrate that Tbx6 and Tbx6r both induce FGF8 expression as well as that of pre-placodal markers, and that Tbx6 can also induce neural crest markers via a ligand dependent mechanism involving FGF8 and Wnt8
Janesick et al., Development 2012
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In the absence of RIPPLY3, TBX1 is required for the expression of Fgf8 and hence, PPE formation