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IDO1 — TNF

Text-mined interactions from Literome

Däubener et al., Adv Exp Med Biol 1999 : For example we have found that TNF-alpha enhances IFN-gamma induced IDO activity and antimicrobial effect in human glioblastoma cells whereas both IFN-gamma mediated effects were blocked by TNF-alpha as well as by IL-1 in a human uroepithelial cell line ... We were able to show that the IL-1 and TNF-alpha mediated inhibition of IFN-gamma induced IDO activity in uroepithelial cells is due to stimulation of inducible nitric oxide synthase ... In human astrocytoma cells, IL-1 and TNF-alpha did not inhibit IDO activity and in concordance with this finding these cells did not show a detectable nitric oxide production
Currier et al., J Interferon Cytokine Res 2000 : Our objectives were to characterize the antichlamydial effect of tumor necrosis factor-alpha (TNF-alpha) on IFN induced IDO activity and to establish the relationship between LPS and TNF-alpha in IDO potentiation ... Both LPS and TNF-alpha enhanced IDO activity and IDO mRNA expression, with maximal IDO induction at 100 ng/ml LPS or 5 ng/ml TNF-alpha ... Anti-TNF-alpha failed to neutralize the effects of LPS treatment, and insufficient TNF-alpha or IL-1 was produced by LPS treated THP-1 cells to account for the enhancing effect of LPS, indicating that the effect of LPS on IDO was independent of TNF-alpha and IL-1
Babcock et al., Cytokine 2000 : Interferon (IFN)-gamma induced indoleamine 2,3-dioxygenase (IDO) activity is enhanced synergistically by interleukin (IL-)1, tumor necrosis factor-alpha (TNF-alpha) and LPS in IFN treated macrophages by increasing IDO mRNA concentration ... These studies demonstrate that IFN treated HeLa cells also exhibit dose dependent enhancement of IDO induction by TNF-alpha and IL-1, with maximal effects at concentrations of 5 ng/ml and 3 ng/ml, respectively
Fujigaki et al., Eur J Immunol 2001 : The present study used IFN-gamma or TNF-alpha gene disrupted mice and IFN-gamma antibody treated mice to demonstrate that lipopolysaccharide (LPS) induced systemic IDO is largely dependent on TNF-alpha rather than IFN-gamma
Shemi et al., J Endotoxin Res 2000 : The effect of pentoxifylline (PXF), nimesulide ( NIM ), indomethacin (INDO) and dexamethasone ( DEX ) on the regulation of PGE2 and TNF-alpha production was tested
Robinson et al., J Interferon Cytokine Res 2003 : Tumor necrosis factor-alpha (TNF-alpha) synergistically enhances the IDO activity induced by IFN-gamma at the level of transcription in human epithelial cells
Adams et al., Microbes Infect 2004 : We found that IFN-gamma induces a strong activation of the tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO) and in addition, that the IFN-gamma induced IDO activity was enhanced in the presence of TNF-alpha
Fieren et al., Immunol Lett 1992 (Peritonitis) : In view of the interregulatory effects between PGE2 and macrophage cytokines ( IL-1 beta and TNF alpha ) in their production, we examined in the present work to what extent the LPS induced release of either IL-1 beta or TNF alpha in vitro from CAPD originated peritoneal macrophages is affected by graded doses of exogenous PGE2 ( range 0-1000 ng/ml ) and by the cyclooxygenase inhibitor indomethacin (INDO) ( 10 ( -6 ) M ) ... INDO induced an approx. two-fold increase in TNF alpha release, but had no effect on IL-1 beta release
Robinson et al., J Interferon Cytokine Res 2005 : In human epithelial cells, interferon-gamma (IFN-gamma) induced IDO expression is transcriptionally enhanced by tumor necrosis factor-alpha(TNF-alpha) ... A transcriptional reporter containing green fluorescent protein ( GFP ) under the control of the IDO regulatory region was used to analyze the contribution of these enhancer elements to synergistic IDO gene expression in response to IFN-gamma and TNF-alpha
Shirey et al., J Interferon Cytokine Res 2006 : Furthermore, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) synergistically increase IFN induced IDO activity
Spalletta et al., Mol Psychiatry 2006 (Brain Ischemia...) : The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia
Shirey et al., Infect Immun 2006 : Gamma interferon ( IFN-gamma ) -induced indoleamine dioxygenase (IDO) , which inhibits chlamydial replication by reducing the availability of tryptophan, is up-regulated by interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha)
Popov et al., J Clin Invest 2006 (Granuloma...) : Reporting on our use of the clinically applied anti-TNF-alpha antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-alpha dependent
Oxenkrug et al., Ann N Y Acad Sci 2007 : Although IDO is strictly an IFN-gamma induced gene product, tumor necrosis factor alpha (TNF-alpha) can synergistically increase the transcriptional activation of the IDO gene in response to IFN-gamma
O'Connor et al., J Neurosci 2009 : Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
Njau et al., Microbes Infect 2009 (Chlamydophila Infections) : Reporting on our use of anti-TNF-alpha antibody adalimumab and varying concentrations of TNF-alpha, we further demonstrate that IDO induction following infection of DCs with C. pneumoniae is TNF-alpha dependent
Däubener et al., Eur J Immunol 1996 (Brain Neoplasms...) : We therefore conclude that both TNF-alpha and IFN-gamma may be involved in the defense against cerebral toxoplasmosis by inducing IDO activity as an antiparasitic effector mechanism in brain cells