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TNF — WWP1
Text-mined interactions from Literome
Zhao et al., Stem Cells 2011
:
Thus,
Wwp1 targets JunB for ubiquitination and degradation in MSCs after chronic exposure to
TNF , and inhibition of Wwp1 in MSCs could be a new mechanism to limit inflammation mediated osteoporosis by promoting their differentiation into osteoblasts
Lin et al., PloS one 2013
:
Knocking down
WWP1 enhanced the TNF-a and IL-6 production induced by LPS, and over-expression of WWP1
inhibited the
TNF-a and IL-6 production induced by LPS, but not by TNF-a