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CASP1 — IL18
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CASP1
—
IL18
(direct interaction, enzymatic study)
Kumar et al., Cytokine 2002*
-
IRef Hprd Interaction:
IL18
—
CASP1
(in vitro)
Akita et al., J Biol Chem 1997*
-
IRef Hprd Interaction:
IL18
—
CASP1
(in vivo)
Akita et al., J Biol Chem 1997*
-
IRef Innatedb Interaction:
IL18
—
CASP1
(unknown, -)
Gaggero et al., Oncogene 2004*
-
IRef Innatedb Interaction:
IL18
—
CASP1
(unknown, -)
Ghayur et al., Nature 1997*
-
IRef Innatedb Interaction:
IL18
—
CASP1
(unknown, -)
Akita et al., J Biol Chem 1997*
-
IRef Innatedb Interaction:
IL18
—
CASP1
(unknown, -)
Bae et al., J Biol Chem 2012*
-
IRef Ophid Interaction:
IL18
—
CASP1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pirhonen et al., J Immunol 1999
:
Since caspase-1 is known to cleave proIL-1 beta and proIL-18 into their mature, active forms, we analyzed the
effect of a specific
caspase-1 inhibitor on virus induced IL-1 beta and
IL-18 production ... Furthermore, the virus induced activation of
caspase-1 is
required for the efficient production of biologically active IL-1 beta and
IL-18
Zeuner et al., Cell Death Differ 1999
:
In addition to the well established
role of
caspase-1 in the production of active IL-1beta and
IL-18 in inflammation,4 an increasing number of reports has recently suggested that caspases may have a function outside of apoptosis
Moldovan et al., Osteoarthritis Cartilage 2000
(Osteoarthritis) :
Diacerhein and rhein reduce the
ICE induced IL-1beta and
IL-18 activation in human osteoarthritic cartilage
Tsutsui et al., Immunol Rev 2000
(Disease Models, Animal...) :
LPS induces
IL-18 secretion from Kupffer cells in a
caspase-1 dependent manner
Sansonetti et al., Immunity 2000
(Dysentery, Bacillary...) :
Caspase-1 activation of IL-1beta and
IL-18 are essential for Shigella flexneri induced inflammation
Lu et al., J Immunol 2000
:
Chlamydia induced secretion of
IL-18 from epithelial cells was regulated at the posttranscriptional level and was
dependent on the activation of
caspase-1
Mehta et al., J Biol Chem 2001
:
Neither IL-1beta nor IL-18 release was prevented by
ICE inhibition, and
IL-18 release was not
induced by ICE activation itself
Seki et al., J Immunol 2001
:
In this study, we investigated the mechanism underlying
caspase-1 mediated
IL-18 secretion
Fantuzzi et al., Eur J Immunol 2001
:
In conclusion, IRF-1
regulates IL-18 production and activity mostly by modulating expression of
caspase-1 and IL-18BP
Itoi et al., Blood 2001
(Acute Disease...) :
Fas ligand induced
caspase-1 dependent accumulation of
interleukin-18 in mice with acute graft-versus-host disease ... These results suggest FasL mediated
caspase-1 dependent
IL-18 secretion in aGVHD in mice
Sugawara et al., J Immunol 2001
:
Caspase-1 was not detected in the cells even after the treatment and the
IL-18 induction was not
inhibited by a caspase-1 inhibitor
Dreher et al., J Leukoc Biol 2002
:
Our results show that infection by S. typhimurium causes
caspase-1 dependent activation of
IL-18 and triggers the release of IL-18 in human DCs
Boileau et al., Arthritis Rheum 2002
(Osteoarthritis) :
At 12 weeks after surgery, cartilage from the femoral condyles and tibial plateaus were processed for immunohistochemistry for ICE,
IL-18 , and protease inhibitor 9 (PI-9), a natural
inhibitor of
ICE , followed by morphometric analysis
Dinarello et al., J Infect Dis 2003
(Bacterial Infections...) :
Although IL-12 is also an IFN-gamma inducing factor, the activity of
IL-18 ( but not IL-12 ) in models of sepsis and death is
dependent on the intracellular cysteine protease
IL-1beta converting enzyme ( caspase-1 )
Guo et al., Blood 2003
:
In the present study we confirm that Fas signaling induces both phenotypic and functional maturation of murine DCs, and we demonstrate that phenotypic maturation is associated with phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2,
activation of
caspase-1 , and secretion of
interleukin-beta ( IL-1beta )
Fujiuchi et al., Int J Tuberc Lung Dis 2003
(Tuberculosis, Pulmonary) :
Altered ICE activity may explain why there is reduced IFN-gamma production from PBMCs ; however, serum
IL-18 is probably not
regulated by
ICE in monocytes in TB patients
Sekiyama et al., Immunity 2005
:
Inhibitors of
caspase-1 , reactive oxygen species, and P38 mitogen activated protein kinase ( MAPK )
suppressed stress induced accumulation of plasma
IL-18
Niyonsaba et al., J Immunol 2005
(MAP Kinase Signaling System) :
Furthermore, because
IL-18 secretion induced by hBDs and LL-37 could not be
suppressed by
caspase-1 or caspase family inhibitors, and because these peptides failed to increase caspase-1 activity, we suggest that hBD- and LL-37 induced IL-18 secretion is probably via a caspase-1 independent pathway
Wang et al., Ann Thorac Surg 2005
(Reperfusion Injury) :
Myocardial tissue was then assessed for products of p38 MAPK activation, expression of tumor necrosis factor,
interleukin-1beta and interleukin-6, and
activation of caspase-1,
caspase-3 and caspase-11
Sekiyama et al., J Med Invest 2005
:
Inhibitors of
caspase-1 , reactive oxygen species and P38 MAPK
prevented stress induced accumulation of plasma
IL-18
Raupach et al., Infect Immun 2006
(Salmonella Infections, Animal) :
Caspase-1 mediated
activation of interleukin-1beta (IL-1beta) and
IL-18 contributes to innate immune defenses against Salmonella enterica serovar Typhimurium infection
Hodge et al., J Interferon Cytokine Res 2006
:
IL-18 reduces NK cell self-destruction during NK-targeted cell killing, and in the presence of staurosporin, a potent apoptotic inducer, IL-18
reduces caspase-3 activity
Omoto et al., J Immunol 2006
(Dermatitis, Atopic) :
Caspase-1 is a well-known
activator of
IL-18 , but caspase-1 knockout mice still have biologically active IL-18
Park et al., J Invest Dermatol 2007
:
Furthermore, we suggest that ACTH induced IL-18 production is via the caspase-1 activation pathway, as
IL-18 production induced by ACTH could be
suppressed by
caspase-1 inhibitor, and ACTH could increase caspase-1 activity
Edelstein et al., Nephrol Dial Transplant 2007
:
We have recently demonstrated that the
caspase-1 mediated production of
IL-18 plays a deleterious role in ischaemic acute renal failure ( ARF ) which is independent of neutrophils and CD4+ T cells
Dinarello et al., Semin Nephrol 2007
(Inflammation...) :
IL-18 is a member of the IL-1 family ; IL-1beta and
IL-18 are related closely, and both
require the intracellular cysteine protease
caspase-1 for biological activity
Boost et al., Intensive Care Med 2007
(Endotoxemia) :
Targeting
caspase-1 by inhalation-therapy :
effects of Ac-YVAD-CHO on IL-1 beta,
IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia
Bauer et al., Dig Dis Sci 2007
(Colitis) :
The increase in
IL-18 and IFN-gamma was
reduced by
ICE inhibition
Li et al., J Immunol 2007
:
Aluminum hydroxide adjuvants activate
caspase-1 and
induce IL-1beta and
IL-18 release
Nagai et al., J Biochem 2007
(Cataract...) :
The gene expression levels causing
IL-18 activation ( IL-18, IL-18 receptor and
caspase-1 ) are increased at 32 days of age, and the expression of mature IL-18 protein in the UPL rat lenses also increases with ageing
Rupper et al., Infect Immun 2008
:
The activation of
caspase-1 by the detection of bacterial products through Nod-like receptors
leads to the secretion of mature interleukin-1beta (IL-1beta) and
IL-18 and the induction of rapid host cell death ( pyroptosis )
Kast et al., JOP : Journal of the pancreas 2008
(Acute Disease...) :
Since ritonavir is well tolerated in short-term use it may therefore prove useful in treating acute pancreatitis by lowering
caspase-1 mediated
IL-18 formation and the many inflammatory mediators downstream from that
Yajima et al., Circulation 2008
(Inflammation...) :
Apoptosis associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein that regulates
caspase-1 dependent IL-1 beta and
IL-18 generation ; however, the role of ASC in vascular injury remains undefined
Iigo et al., Biochimie 2009
(Neoplasms) :
The increase of mature
IL-18 by macrophages was
inhibited by
caspase-1 inhibitor : caspase-1 is known to cleave the proform of IL-18 to produce active mature IL-18
Bulosan et al., Immunol Cell Biol 2009
(Sjogren's Syndrome) :
Caspase-1 , a critical factor for interleukin (IL)-1beta and IL-18 secretion,
resulted in an elevated level of
IL-18 in saliva
He et al., American journal of physiology. Renal physiology 2009
(Acute Kidney Injury) :
We previously reported in ischemic acute kidney injury ( AKI ) in mice that
caspase-1 mediated production of
interleukin-18 (IL-18) is pathogenic and that macrophage depletion by liposome encapsulated clodronate ( LEC ) is protective
Halade et al., J Immunol 2010
(Lupus Erythematosus, Systemic...) :
Further, FO-DHA lowered LPS mediated increases in serum IL-18 levels and
caspase-1 dependent cleavage of
pro-IL-18 to mature IL-18 in kidneys
Dinarello et al., Expert Rev Clin Immunol 2005
:
IL-18 is a member of the IL-1 family ; IL-1beta and
IL-18 are closely related, and both
require the intracellular cysteine protease
caspase-1 for biologic activity
Omoto et al., J Dermatol Sci 2010
(Inflammation) :
Caspase-1 is the authentic IL-18 processing enzyme and is
essential for
IL-18 release from monocyte/macrophage lineage cells
Miao et al., Nat Immunol 2010
(Salmonella Infections) :
Macrophages mediate crucial innate immune responses via
caspase-1 dependent processing and secretion of interleukin 1ß (IL-1ß) and
IL-18
Shushanov et al., Bull Exp Biol Med 2010
:
Insulin-like growth factor-1 and insulin inhibit
caspase-3/7 activation
initiated by
interleukin-1ß in the rat eye retinal neurons
Zhang et al., American journal of physiology. Renal physiology 2011
(Ureteral Obstruction) :
Renal obstruction
induced a significant increase in
IL-18 production, renal tubular cell apoptosis,
caspase activation, and FasL expression
Han et al., Exp Dermatol 2011
(Dermatitis, Atopic...) :
The increased enzymatic activity of
caspase-1 in the dorsal skin of the kanamycin administered mice
increased the mRNA expressions of IL-1ß and
IL-18
Eitel et al., Frontiers in microbiology 2010
:
Inflammasomes regulate
caspase-1 dependent production of the key inflammatory cytokines IL-1ß and
IL-18 as well as pyroptotic cell death in L. monocytogenes infected cells
Zambetti et al., Immunol Res 2012
(Disease Models, Animal...) :
The Nucleotide binding oligomerization domain, Leucine-rich Repeat and Pyrin domain containing ( NLRP ) family and corresponding inflammasomes are important intracellular sensors of microbial pathogens and stress signals that promote
caspase-1 mediated release of IL-1ß and
IL-18
Levinsohn et al., PLoS Pathog 2012
:
Their activation in response to a wide range of intracellular danger signals leads to formation of the inflammasome,
caspase-1 activation , rapid programmed cell death ( pyroptosis ) and maturation of IL-1ß and
IL-18
Jacobs et al., J Leukoc Biol 2012
(Virus Diseases) :
Upon pathogen infection, some NLR proteins form large complexes, called inflammasomes, which activate
caspase-1 and
induce the production of active IL-1ß and
IL-18
Nasti et al., Photochem Photobiol 2012
(Inflammation) :
Normal skin contains only low levels of inactive precursor forms of IL-1ß and
IL-18 , which
require caspase 1-mediated proteolysis for their maturation and secretion
Liao et al., Inflamm Res 2013
:
Lipopolysaccharide/adenosine triphosphate mediated signal transduction in the regulation of NLRP3 protein expression and
caspase-1 mediated
interleukin-1ß secretion
Huang et al., Scientific reports 2013
:
In the present study, the HSM extract suppresses IL-1ß and
IL-18 secretion, and ATP induced
activation of
caspase-1
Kotas et al., Proc Natl Acad Sci U S A 2013
:
Caspase-1 dependent production of the inflammatory cytokines IL-1 and
IL-18 has also been implicated in the regulation of appetite, body weight, glucose homeostasis, and lipid metabolism
Lin et al., PloS one 2013
(Plaque, Atherosclerotic) :
In in-vitro experiments showed that ox-LDL induced
caspase-1 activation and this activation was
required for ox-LDL induced macrophages lysis, IL-1ß and
IL-18 production as well as DNA fragmentation
Aachoui et al., Curr Opin Microbiol 2013
(Communicable Diseases) :
Caspase-1 then
promotes the secretion of IL-1ß and
IL-18 and a rapid form of lytic programmed cell death termed pyroptosis
Piper et al., PloS one 2013
:
Release of these cytokines was not dependent on cell death, and only IL-1ß and
IL-18 release was
dependent on
caspase-1 catalytic activity
Silva et al., J Immunol 2013
(Chagas Disease...) :
Following pathogen infection, NLRs form large molecular platforms, termed inflammasomes, which activate
caspase-1 and
induce the production of active IL-1ß and
IL-18
Gu et al., Science 1997
:
Activation of
interferon-gamma inducing factor mediated by
interleukin-1beta converting enzyme
Akita et al., J Biol Chem 1997
:
Involvement of
caspase-1 and caspase-3 in the production and processing of mature human
interleukin 18 in monocytic THP.1 cells
Puren et al., J Clin Invest 1998
:
IL-18 is synthesized as a precursor molecule without a signal peptide but
requires the
IL-1beta converting enzyme ( ICE, caspase-1 ) for cleavage into a mature peptide
Tone et al., J Immunol 1997
:
IL-18 is known to be synthesized as a precursor, pro-IL-18, and its maturation is
controlled by
IL-1beta converting enzyme (ICE)
Culhane et al., Mol Psychiatry 1998
:
We demonstrate that caspase-1 also cleaves rat
IL-18 in vitro and that the
caspase inhibitor, zVAD-DCB
inhibits this cleavage