Lu et al., Cancer Res 2011
(Nasopharyngeal Neoplasms) :
Mechanistic investigations revealed that miR-26a suppressed the expression of c-myc, the cyclin D3 and E2, and the cyclin dependent kinase CDK4 and CDK6 while enhancing the expression of CDK inhibitors p14(ARF) and p21 ( CIP1 ) in an EZH2 dependent manner
Wu et al., J Biol Chem 2011
:
Here, we demonstrate that Ezh2 can be regulated by the cyclin dependent kinase , CDK1, which phosphorylates Ezh2 at threonines 345 and 487