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CA2 — TNF

Text-mined interactions from Literome

Carlstedt et al., Biosci Rep 1999 : Neither IL-6 nor TNF-alpha , affected cytoplasmic Ca2+ of the cells
Liu et al., Proc Soc Exp Biol Med 2000 (Calcium Signaling) : Ca2+ release from intracellular stores was strongly stimulated by acetylcholine (ACh) and ATP, but not by norepinephrine ( NA ), epidermal growth factor (EGF), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFalpha)
Wang et al., J Immunol 2001 (Breast Neoplasms...) : The expression of TNF , in contrast, is mediated by PKC, but not by Ca2+
Wang et al., Acta Pharmacol Sin 2001 : To study the effect of tumor necrosis factor alpha (TNFalpha) on intracellular free Ca2+ concentration ([Ca2+]i) and the effects of verapamil ( Ver ), cyproheptadine ( Cyp ), and anisodamine ( Ani ) on TNFalpha induced [ Ca2+ ] i changes in single endothelial cell, and to explore the mechanisms of TNFalpha mediated shock and antishock actions of Cyp and Ani
Jeong et al., Cell Signal 2002 (Calcium Signaling) : These observations demonstrate that the intracellular Ca2+ may play an important role in IgE induced TNF-alpha and IL-6 secretion from mast cells via IKKbeta activation
Richter et al., Restor Neurol Neurosci 1998 : Tumor necrosis factor-a induces oxygen radicals in mitochondria through ceramides, and the recently discovered mitochondrial nitric oxide synthase profoundly stimulates Ca2+ release from mitochondria through formation of nitrogen monoxide and peroxynitrite
Miłoszewska et al., Arch Immunol Ther Exp (Warsz) 1991 : TNF-alpha induced rapid elevation of intercellular Ca2+ level in all studied cells
Keller et al., Cytokine 2006 : Here we investigated whether skeletal myocytes produce IL-6 in a Ca2+/calcineurin dependent manner, and whether TNF-alpha , an inducer of IL-6, is affected by these stimuli
Corkey et al., J Clin Invest 1991 (Reye Syndrome) : To determine whether this disorder involves a genetically determined abnormal response to cytokines, the effects of tumor necrosis factor (TNF) and IL-1 on intracellular free Ca2+ were compared in cultured skin fibroblasts from control subjects and patients with RS ... IL-1 and TNF caused rapid, transient, and concentration dependent increases in cytosolic free Ca2+
Park et al., Cell Signal 2010 (Alzheimer Disease) : Impaired TNF-alpha control of IP3R mediated Ca2+ release in Alzheimer 's disease mouse neurons ... Herein, we describe regulation inherent to 3xTg-AD neurons, which results in the loss of TNF-alpha mediated enhancement of inositol 1,4,5 trisphosphate ( IP3R ) -mediated Ca2+ release ... Through the experimental isolation of each AD-related transgene, it was determined that expression of the PS1M146V transgene product is responsible for the loss of the TNF-alpha effect on IP3R mediated Ca2+ release
Zhang et al., Can J Physiol Pharmacol 2010 (Calcium Signaling...) : Interestingly, endothelial nitric oxide synthase (eNOS) promotes TNF-alpha expression by enhancing p38 MAPK activation, whereas neuronal NOS (nNOS) inhibits TNF-alpha production by reducing Ca2+ dependent ERK1/2 activity
Yuo et al., J Immunol 1989 : TNF did not affect an increase in [Ca2+ ] i stimulated by the Ca2+ mobilizing agonists, except Con A. Con A-induced increase in [Ca2+ ] i was enhanced by TNF in a dose dependent manner
Franz et al., Biochem Biophys Res Commun 1994 (Adenocarcinoma...) : Tumor necrosis factor-alpha induces the expression of carbonic anhydrase II in pancreatic adenocarcinoma cells
Baumgartner et al., J Immunol 1994 : Unlike constitutive secretion, however, the secretion of TNF was highly regulated by Ca2+ and protein kinase C. Studies with various stimulants and inhibitors indicated that simultaneous mobilization of Ca2+ and activation of protein kinase C were sufficient signals for secretion although optimal production of TNF may be dependent on additional synergistic signals
Raponi et al., Antimicrob Agents Chemother 1993 : Germ tube negative mutant CA2 induced the release of TNF-alpha at levels significantly ( P < 0.05 ) lower than those induced by clinical isolate CA3, while no major differences were observed between the two strains with regard to their capacity to induce the release of IL-6
Krown et al., FEBS Lett 1995 : TNF alpha receptor expression in rat cardiac myocytes : TNF alpha inhibition of L-type Ca2+ current and Ca2+ transients
Marinovich et al., Exp Cell Res 1996 : These findings suggest that TPT increases intracellular Ca2+ , alters actin polymerization and the cytoskeleton, and induces NF-kappaB activation, TNF-alpha synthesis, DNA degradation, and apoptosis
West et al., J Trauma 1996 (Endotoxemia...) : Intracellular Ca2+ is required for TNF protein release by naive macrophages and TNF mRNA transcription of both naive and LPSp reprogrammed cells, however LPSa stimulated IL-1 release in peritoneal macrophages does not require Ca2+ dependent signaling pathways
Lichtman et al., Am J Physiol 1996 : Endocytosis and Ca2+ are required for endotoxin stimulated TNF-alpha release by rat Kupffer cells
Köller et al., Brain 1996 : We conclude that TNF-alpha induces an increase of intracellular Ca2+ and a depolarization in astrocytes with the consequence of disturbing voltage dependent glial functions such as regulation of local ion concentrations and glutamate uptake
Amrani et al., Am J Physiol 1997 : We have previously shown that tumor necrosis factor (TNF)-alpha , a cytokine involved in asthma, enhances Ca2+ responsiveness to bronchoconstrictor agents in cultured human airway smooth muscle ( ASM ) cells
Teshima et al., Inflamm Res 1998 (Leukemia, Basophilic, Acute) : Ca2+-ATPase inhibitors and PKC activation synergistically stimulate TNF-alpha production in RBL-2H3 cells ... To investigate the effect of Ca2+-ATPase inhibitors on the production of TNF-alpha in rat basophilic leukemia ( RBL-2H3 ) cells ... All Ca2 -- ATPase inhibitors ( TG, CPA, DTBHQ and DTAHQ ) induced TNF-alpha release in a dose dependent manner ... These results suggest 1 ) that [ Ca2+ ] i increase and subsequent activation of protein kinase C is necessary for the release of TNF-alpha, and they work synergistically, 2 ) that the TNF-alpha release induced by Ca2+-ATPase inhibitors can be regulated at the transcriptional level
West et al., Shock 1998 : We sought to determine whether carbonic anhydrase inhibition with acetazolamide would prevent CO2 mediated inhibition of LPS stimulated TNF release
Soboloff et al., Biol Reprod 1999 : We previously demonstrated that TNF-alpha induces a small, delayed follicular stage dependent increase in intracellular Ca2+ concentration ([Ca2+]i) in hen granulosa cells and promotes carbachol ( Cch ) -induced mobilization of Ca2+ from intracellular stores in cells otherwise unresponsive to the cytokine ... The focus of the current study was to examine the role of ceramide in TNF-alpha induced Ca2+ regulation
Pizanis et al., J Mol Med (Berl) 1999 (Shock, Hemorrhagic) : The present study investigated the role of TNF-alpha in oxidative membrane injury and altered hepatocyte Ca2+ regulation, both of which are critical steps in cellular dysfunction during ischemia/reperfusion events