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CDK1 — TYR

Text-mined interactions from Literome

Wells et al., J Cell Sci 1999 : In higher eukaryotes, Cdc2 activity is in part regulated by inhibitory phosphorylation of Thr14 and Tyr15 , catalyzed by Wee1 and Myt1, which prevents catastrophic premature entry into mitosis
Wang et al., Cell Growth Differ 2000 : It inhibits Cdc-2 activity by phosphorylating Tyr15 and arrests cells at G2-M phase
Hashimoto et al., Mol Carcinog 2003 (Carcinoma, Hepatocellular...) : In particular, augmentation of CDK inhibitors p21cip1 and p27kip1 and Wee1 kinase and diminution of CDC25C phosphatase coincided with induced Tyr-15 phosphorylation and inhibition of CDC2 ... These findings suggest that TGF beta 1 induced G2 arrest in Hep3B at least in part through stabilization of Wee1 and subsequent increase in Tyr-15 phosphorylation and inhibition of CDC2
Gaul et al., J Cancer Res Clin Oncol 2008 (Multiple Myeloma) : The Chk2 substrate Cdc25A phosphatase is degraded and Cdc2 is inhibited by inhibitory phosphorylation of Tyr15 accompanied by increased cyclin B levels
Poon et al., J Biol Chem 1996 : Taken together, these results suggest that different CDKs are inhibited by different mechanisms following UV-induced DNA damage : Cdk2 is inhibited by the elevated level of p21 ; Cdk4 is inhibited by cooperation of p21 with other CDK inhibitors, like p27, and possibly by phosphorylation ; and Cdc2 is inhibited by Thr-14/Tyr-15 phosphorylation
Poon et al., Cancer Res 1997 : Consistent with this, Thr14/Tyr15 phosphorylation was induced when Cdc2 kinase activity was inhibited with butyrolactone-I