Ramanadham et al., J Biol Chem 1999
(Insulinoma) :
An 84-kDa group VI phospholipase A2 ( iPLA2 ) that does not require Ca2+ for catalysis has been cloned from Chinese hamster ovary cells, murine P388D1 cells, and pancreatic islet beta-cells
Jenkins et al., Cardiovasc Res 2009
:
Importantly, iPLA2beta has been demonstrated to be activated by ischaemia through elevation of the concentration of myocardial fatty acyl-CoA, which abrogates Ca2+/CaM mediated inhibition of iPLA2beta