◀ Back to IL1A

IL1A — SERPINE2

Text-mined interactions from Literome

Boivin et al., Exp Dermatol 2006 : IL-1alpha also increased mRNA transcript levels of protease-nexin-1 , a secreted serine protease inhibitor expressed in the dermal papilla of anagen-stage hair follicles
Guttridge et al., J Biol Chem 1993 : In normal human fibroblasts, interleukin-1 (IL-1) beta stimulated the synthesis and secretion of PN-1 ... Nuclear run-on assays indicated that IL-1 modestly increased the rate of PN-1 transcription ... Thus, our experiments demonstrate that IL-1 and DXM, which function biologically in different fashions, regulate the synthesis of PN-1 by separate molecular mechanisms ... While DXM directly regulates PN-1 at the level of transcription, IL-1 in the presence of ongoing protein synthesis regulates PN-1 production predominantly in a post-transcriptional fashion by increasing the half-life of the PN-1 mRNA