UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to BDNF

BDNF — CDC42

Pathways - manually collected, often from reviews:

NCI Pathway Database Neurotrophic factor-mediated Trk receptor signaling: CDC42/GDP complex (CDC42) → BDNF (dimer)/TRKB complex (BDNF-NTRK2) (modification, collaborate)
Yuan et al., Nat Cell Biol 2003 *
Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Cheung et al., PLoS Biol 2007 : In addition, we found that Cdk5 is involved in BDNF induced activation of Rho GTPase Cdc42 , which is essential for BDNF triggered dendritic growth ... Our observations therefore reveal an unanticipated role of Cdk5 in TrkB mediated regulation of dendritic growth through modulation of BDNF induced Cdc42 activation
Lindsley et al., Alcohol Clin Exp Res 2011 : In contrast, ethanol exposure inhibited BDNF induced Rac1/Cdc42 activation in a dose dependent manner and increased RhoA activation at the highest concentration tested