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Bliziotes et al., Bone 2001
(Osteosarcoma) :
5-HT potentiates the PTH induced increase in AP-1 activity in UMR cells
Cheung et al., J Cell Physiol 2005
(Osteosarcoma) :
Increased expression of G11alpha in osteoblastic cells enhances parathyroid hormone activation of phospholipase C and AP-1 regulation of matrix metalloproteinase-13 mRNA ... There was a 2.5 +/- 0.35 fold increase in maximal PTH-stimulation of c-jun mRNA and smaller but significant increases in c-fos accompanied by increased basal and PTH stimulated AP-1 binding in cells expressing increased G ( 11 ) alpha
Bliziotes et al., J Musculoskelet Neuronal Interact 2002
:
5-HT potentiates the PTH induced increase in AP-1 activity in UMR 106-H5 cells
Koe et al., Calcif Tissue Int 1997
(Bone Neoplasms...) :
Thus, it appears that the differential temporal stimulation of the AP-1 genes by PTH and PMA, particularly an increase in jun-B at the same time as c-fos and c-jun, explains the difference seen in their ability to induce transcription of collagenase