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CDH5 — KDR
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer)/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-CDH5-CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
(modification, collaborate)
Carmeliet et al., Cell 1999
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VE-cadherin/beta catenin/alpha catenin complex (CTNNB1-CTNNA1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
IQGAP1 (IQGAP1)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
-
NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2:
VEGFR2 (dimer)/VEGFA (dimer) complex (KDR-VEGFA)
→
VEGFR2 (dimer)/VEGFA (dimer)/IQGAP1/VE-cadherin/beta catenin/alpha catenin complex (KDR-VEGFA-IQGAP1-CDH5-CTNNB1-CTNNA1)
(modification, collaborate)
Carmeliet et al., Cell 1999, Yamaoka-Tojo et al., Arterioscler Thromb Vasc Biol 2006
Evidence: physical interaction
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CDH5
—
KDR
(physical association, affinity chromatography technology)
Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
MIPS CORUM ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex:
ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex complex (CDH5-CTNNB1-KDR-TJP1)
Bhattacharya et al., Journal of molecular signaling 2008*
-
IRef Hprd Interaction:
CDH5
—
KDR
(in vivo)
Carmeliet et al., Cell 1999, Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
IRef Intact Interaction:
Complex of CTNNB1-CDH5-KDR-TJP1-TJP1-CTNNB1-CDH5-KDR
(association, anti bait coimmunoprecipitation)
Bhattacharya et al., Journal of molecular signaling 2008*
-
IRef Intact Interaction:
CDH5
—
KDR
(physical association, coimmunoprecipitation)
Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
IRef Ophid Interaction:
CDH5
—
KDR
(aggregation, confirmational text mining)
Carmeliet et al., Cell 1999
-
IRef Ophid Interaction:
CDH5
—
KDR
(aggregation, confirmational text mining)
Zanetti et al., Arterioscler Thromb Vasc Biol 2002*
-
IRef Ophid Interaction:
CDH5
—
KDR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Shih et al., Am J Pathol 2002
(Adenocarcinoma...) :
Relative to control, in dermis highly stimulated by VEGF, the Ang-2 mRNA transcript numbers increased 35-fold, PECAM-1 and
VE-cadherin increased 10-fold, Tie-1 increased 8-fold,
KDR and Flt-1 each
increased 4-fold, and Ang-1 increased 2-fold
Calera et al., Exp Cell Res 2004
(MAP Kinase Signaling System) :
In this study, we report that stable overexpression of
VE-cadherin in two different endothelial cells
induced an increase in
VEGFR-2 protein levels ...
VE-cadherin induced changes in
VEGFR-2 levels were paralleled by a corresponding shift in the VEGF dependent activation of MAPK signaling, which demonstrated the functional relevance of varying the VEGFR-2 levels ... These results support the existence of a novel layer of functional
regulation of
VEGFR-2 by
VE-cadherin
Lin et al., Cancer Res 2007
(Carcinoma, Lewis Lung...) :
Thus, the loss of Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling due to lack of Cav-1 inhibition of VEGFR-2 or decreased
VE-cadherin mediated
VEGFR-2 phosphorylation
Zeng et al., Heart Vessels 2012
:
Mini-TyrRS was able to increase the protein expression of
VEGFR-2 in the
presence of
VE-cadherin , while no stimulatory effect of mini-TyrRS was detected when VE-cadherin was not present
Liu et al., Blood 2012
(Wnt Signaling Pathway) :
We show that ER71 could inhibit Wnt signaling in VE-cadherin independent as well as
VE-cadherin dependent
VE-cadherin/ß-catenin/Flk-1 complex formation