Gene interactions and pathways from curated databases and text-mining

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CDH5 — KDR

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shih et al., Am J Pathol 2002 (Adenocarcinoma...) : Relative to control, in dermis highly stimulated by VEGF, the Ang-2 mRNA transcript numbers increased 35-fold, PECAM-1 and VE-cadherin increased 10-fold, Tie-1 increased 8-fold, KDR and Flt-1 each increased 4-fold, and Ang-1 increased 2-fold
Calera et al., Exp Cell Res 2004 (MAP Kinase Signaling System) : In this study, we report that stable overexpression of VE-cadherin in two different endothelial cells induced an increase in VEGFR-2 protein levels ... VE-cadherin induced changes in VEGFR-2 levels were paralleled by a corresponding shift in the VEGF dependent activation of MAPK signaling, which demonstrated the functional relevance of varying the VEGFR-2 levels ... These results support the existence of a novel layer of functional regulation of VEGFR-2 by VE-cadherin
Lin et al., Cancer Res 2007 (Carcinoma, Lewis Lung...) : Thus, the loss of Cav-1 increases tumor permeability and growth and that may relate to enhanced VEGF signaling due to lack of Cav-1 inhibition of VEGFR-2 or decreased VE-cadherin mediated VEGFR-2 phosphorylation
Zeng et al., Heart Vessels 2012 : Mini-TyrRS was able to increase the protein expression of VEGFR-2 in the presence of VE-cadherin , while no stimulatory effect of mini-TyrRS was detected when VE-cadherin was not present
Liu et al., Blood 2012 (Wnt Signaling Pathway) : We show that ER71 could inhibit Wnt signaling in VE-cadherin independent as well as VE-cadherin dependent VE-cadherin/ß-catenin/Flk-1 complex formation