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MYC — TRRAP

Pathways - manually collected, often from reviews:

• NCI Pathway Database C-MYC pathway: TRRAP/TIP60 complex (TRRAP-KAT5) → MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) (modification, collaborate)
  Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database C-MYC pathway: TRRAP/TIP60 complex (TRRAP-KAT5) → MYC/Max complex (MYC-MAX) (modification, collaborate) Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database C-MYC pathway: BAF53 (ACTL6A) → MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) (modification, collaborate)
  Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → TIP49A/TIP49B complex (RUVBL1-RUVBL2) (modification, collaborate)
  Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → MYC/Max complex (MYC-MAX) (modification, collaborate) Wood et al., Mol Cell 2000, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → CAD (CAD) (transcription, activates) Eberhardy et al., J Biol Chem 2001, Frank et al., EMBO Rep 2003, Boyd et al., Proc Natl Acad Sci U S A 1998, Bush et al., Genes Dev 1998
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → NME1 (NME1) (transcription, activates) Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Greenberg et al., Oncogene 1999, Faiola et al., Mol Cell Biol 2005, Liu et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database C-MYC pathway: STAF65G (SUPT7L) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF10 (TAF10) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF12 (TAF12) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: SPT3 (SUPT3H) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max complex (MYC-MAX) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: TAF9 (TAF9) → MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database C-MYC pathway: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → TRRAP/GCN5 complex (TRRAP-KAT2A) (modification, collaborate)
  McMahon et al., Mol Cell Biol 2000, Park et al., Genes Dev 2001, Liu et al., J Biol Chem 2003, Liu et al., Mol Cell Biol 2008, McMahon et al., Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → PTMA (PTMA) (transcription, activates) Frank et al., EMBO Rep 2003, Eilers et al., EMBO J 1991, Gaubatz et al., Mol Cell Biol 1994
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → MYC/Max/RPL11 complex (MYC-MAX-RPL11) (transcription, activates)
  Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → nucleus (EP300/CREBBP) (transcription, activates) Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → Nucleolin (NCL) (transcription, activates) Greasley et al., Nucleic Acids Res 2000, Frank et al., EMBO Rep 2003, Adhikary et al., Cell 2005, Dai et al., EMBO J 2007
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → nucleus (EP300/CREBBP) (transcription, activates) Bouchard et al., EMBO J 1999, Bouchard et al., Genes Dev 2001, Vervoorts et al., EMBO Rep 2003
  Evidence: mutant phenotype, assay, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → GPAT (GPAM) (transcription, activates) Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/GCN5/STAF65G/SPT3/TAF9/TAF10/TAF12/core Mediator complex (MYC-MAX-SUPT7L-SUPT3H-TAF9-TAF10-TAF12-TRRAP-KAT2A) → HSP60 (HSPD1) (transcription, activates) Frank et al., Genes Dev 2001, Liu et al., Mol Cell Biol 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: MYC/Max/TRRAP/TIP60/TIP49A/TIP49B/BAF53 complex (MYC-MAX-ACTL6A-RUVBL1-RUVBL2-TRRAP-KAT5) → HSP60 (HSPD1) (transcription, activates) Frank et al., Genes Dev 2001, Frank et al., EMBO Rep 2003
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional activation: TRRAP (TRRAP) → MYC/Max complex (MYC-MAX) (rRNA transcription, activates) Poortinga et al., EMBO J 2004*, Arabi et al., Nat Cell Biol 2005*, Grandori et al., Nat Cell Biol 2005*
  Evidence: mutant phenotype, assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: MYC — TRRAP Liu et al., J Biol Chem 2003
• IRef Bind_translation Interaction: MYC — TRRAP (affinity chromatography technology) Liu et al., J Biol Chem 2003
• IRef Bind_translation Interaction: MYC — TRRAP (coimmunoprecipitation) Liu et al., J Biol Chem 2003
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) McMahon et al., Mol Cell Biol 2000
• IRef Biogrid Interaction: MYC — TRRAP (direct interaction, pull down) McMahon et al., Cell 1998
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Park et al., Mol Cell Biol 2002
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Brès et al., Mol Cell 2009
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Cowling et al., Mol Cell Biol 2006*
• IRef Biogrid Interaction: MYC — TRRAP (colocalization, imaging technique) Frank et al., Genes Dev 2001
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Kim et al., Cell 2010
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Biogrid Interaction: MYC — TRRAP (physical association, affinity chromatography technology) Liu et al., J Biol Chem 2003
• IRef Biogrid Interaction: MYC — TRRAP (association, biochemical) Liu et al., J Biol Chem 2003
• MIPS CORUM cMYC-ATPase-helicase complex: cMYC-ATPase-helicase complex complex (ACTL6A-MYC-RUVBL1-RUVBL2-TRRAP) Wood et al., Mol Cell 2000
• MIPS CORUM c-MYC-ATPase-helicase complex: c-MYC-ATPase-helicase complex complex (ACTL6A-MYC-RUVBL1-RUVBL2-TRRAP) Park et al., Mol Cell Biol 2002
• IRef Corum Interaction: Complex of 16 proteins (association, anti bait coimmunoprecipitation) Park et al., Mol Cell Biol 2002
• IRef Dip Interaction: MYC — TRRAP (physical association, coimmunoprecipitation) McMahon et al., Cell 1998
• IRef Dip Interaction: MYC — TRRAP (physical association, coimmunoprecipitation) Liu et al., J Biol Chem 2003
• IRef Hprd Interaction: TRRAP — MYC (in vivo) McMahon et al., Cell 1998
• IRef Hprd Interaction: TRRAP — MYC (in vitro) McMahon et al., Cell 1998
• IRef Intact Interaction: MYC — TRRAP (physical association, anti bait coimmunoprecipitation) Ewing et al., Molecular systems biology 2007
• IRef Intact Interaction: MYC — TRRAP (physical association, anti tag coimmunoprecipitation) McMahon et al., Cell 1998
• IRef Intact Interaction: MYC — TRRAP (physical association, coimmunoprecipitation) McMahon et al., Cell 1998
• IRef Intact Interaction: Complex of 222 proteins (association, tandem affinity purification) Koch et al., Cell cycle (Georgetown, Tex.) 2007
• IRef Ophid Interaction: MYC — TRRAP (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Bouchard et al., Genes Dev 2001 : Regulation of cyclin D2 gene expression by the Myc/Max/Mad network : Myc dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter ... Binding of Myc induces cyclin D2 expression and histone acetylation at a single nucleosome in a MycBoxII/TRRAP dependent manner
Liu et al., J Biol Chem 2003 : Myc induces TRRAP recruitment and histone hyperacetylation at specific Myc activated genes in vivo