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EIF4E — RPS6KB1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: EIF4E → RPS6KB1 (directlyIncreases, EIF4E Activity)
  Evidence: S6K and RSK phosphorylate eIF4B at Ser422, thus enhancing its interaction with the eIF3 and promoting protein translation (Shahbazian et al., 2006).
• BioCarta regulation of eif-4e and p70s6 kinase: 48S/S6 complex (PSMC4-EIF4G1-PABPC1-EIF4E-EIF4A1) → p70S6K (RPS6KB1) (transcription, collaborate)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of EIF3B-NCBP1-RPS6KB1-EIF3B-EIF4E-RPS6KB1-NCBP1-EIF4E (association, anti bait coimmunoprecipitation) Ma et al., Cell 2008
• IRef Intact Interaction: Complex of RPS6-EIF4E-RPS6KB1 (association, anti bait coimmunoprecipitation) Ma et al., Cell 2008
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Ma et al., Cell 2008

Text-mined interactions from Literome

Kimball et al., Am J Physiol Endocrinol Metab 2000 : The results suggest that feeding stimulates hepatic protein synthesis through an mTOR dependent process involving enhanced eIF4F complex formation and activation of S6K1
Reiter et al., J Nutr 2005 : Both eIF4F assembly and activation of S6K1 have been linked to upregulated translation of a subset of mRNAs