Lazaro et al., Genes Dev 2002
:
We have found that cyclin D-cdk activity blocks the association of MEF2C with the coactivator protein GRIP-1 and thereby inhibits the activity of MEF2 Molkentin et al., Mol Cell Biol 1996
:
MEF2 mutants that are defective for DNA binding act as dominant negative mutants and can inhibit activation of MEF2 dependent genes by wild-type MEF2C