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HMOX1 — PI3

Text-mined interactions from Literome

Lee et al., Circulation 2004 : Simvastatin activated p38 and Akt in VSMCs, and the respective inhibitors of p38 and phosphoinositide 3-kinase (PI3K) greatly reduced the level of simvastatin induced HO-1 , which suggests the involvement of p38 and the PI3K-Akt pathway in HO-1 induction
Lin et al., Eur J Pharmacol 2007 : In this study, we investigated the involvement of phosphoinositide-3-OH-kinase (PI3K)/Akt and the nuclear factor-kappaB (NF-kappaB) signaling pathway in TGF-beta1 induced HO-1 expression in human lung epithelial cells ( A549 )
Hsu et al., J Cell Physiol 2008 : Herein, we show that Curcumin dose dependently induced HO-1 expression and HO-1 activity through the activation of PKCalpha, PKCdelta/ERK1/2, p38alpha, and PI3-kinase
Liu et al., Mol Pharmacol 2009 : However, the YC-1 mediated induction of HO-1 was inhibited by the phosphatidylinositol-3-kinase (PI3K) inhibitors wortmannin and 2- ( 4-morpholinyl ) -8-phenyl-1 ( 4H ) -benzopyran-4-one hydrochloride ( LY294002 )
Park et al., Biochem Biophys Res Commun 2009 : HO-1 expression by PGE ( 2 ) was inhibited by LY294002, PI3K inhibitor and H89, PKA inhibitor
Chen et al., Int Immunopharmacol 2012 : In addition, berberine induced HO-1 expression was attenuated by PI 3-kinase ( phosphatidylinositol 3-kinase ) inhibitors LY294002 and wortmannin, and an AKT inhibitor
Koriyama et al., Brain Res 2013 : We found that R-LA activates Akt, and HO-1 induction by R-LA ( involving Nrf2 translocation to the nucleus ) was suppressed by phosphoinositide 3-kinase (PI3K) inhibitors
Pan et al., Biochim Biophys Acta 2013 : In addition, DSC concentration-dependently induced HO-1 expression associated with nuclear translocation of nuclear factor-erythroid 2 related factor 2 ( Nrf-2 ), while the effect of DSC was inhibited by a phosphoinositide 3-kinase (PI3K) inhibitor LY294002
Li et al., Marine drugs 2013 : Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not
Huang et al., Toxicol Appl Pharmacol 2013 (Inflammation) : On the other hand, LTA enhanced HO-1 expression was attenuated by p38 and PI3-kinase inhibitors
Deng et al., Cell Biol Toxicol 2013 : Evaluation of signaling pathways showed that a phosphatidylinositol 3-kinase (PI3K) inhibitor ( LY294002 ), but not an ERK 1/2 inhibitor ( PD98059 ) or a p38 MAPK ( SB203580 ), significantly down-regulated PM2.5 induced Nrf2 nuclear translocation and HO-1 mRNA expression, indicating PI3K/AKT is involved in the signaling pathway leads to the PM2.5 induced nuclear translocation of Nrf2 and subsequent Nrf2 mediated HO-1 transcription