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KRAS — TP53

Text-mined interactions from Literome

Kato et al., J Biol Chem 2002 (Cell Transformation, Neoplastic) : An oncogenic K-Ras 4B mutant significantly increased MDM2 proteins coprecipitated with p53, and suppressed p53 transcriptional activity ... In turn, DNER exerted its function to decrease MDM2 proteins coprecipitated with p53, followed by the stimulation of p53 activity in the presence of the oncogenic K-Ras 4B mutant
Daikoku et al., Cancer Res 2006 (Disease Models, Animal...) : These models include : ( a ) deletion of both p53 and Rb, ( b ) induction of the transforming region of SV40 under the control of Mullerian inhibitory substance type II receptor, or ( c ) activation of K-Ras in the absence of Pten locally in the ovarian surface epithelium
Lee et al., Neoplasia (New York, N.Y.) 2009 (Neoplasms) : Thus, elimination of Snail through si-RNA can induce p53 in K-Ras mutated cells, whereas Snail and mutant K-Ras can suppress p53 in regardless of K-Ras status ... Chemicals, isolated from inhibitor screening of p53-Snail binding, can block the Snail mediated p53 suppression and enhance the expression of p53 as well as the transcriptional activity of p53 in an oncogenic K-Ras dependent manner
de Bruijn et al., Br J Cancer 2010 (Colorectal Neoplasms) : Oncogenic KRAS sensitised colorectal tumour cells to oxaliplatin and 5-FU in a p53 dependent manner and promoted p53 phosphorylation at Ser37 and Ser392, without affecting p53 stabilisation, p21 induction, or cell-cycle arrest
Haigis et al., Nat Genet 2011 (MAP Kinase Signaling System...) : A new study implicates the Jnk pathway signaling in the activation of p53 in response to both K-Ras and Neu oncogene expression
Sevignani et al., J Clin Invest 1998 (Cell Transformation, Neoplastic...) : Distinct genetic abnormalities ( loss-of-function mutations of APC and p53 and oncogenic activation of Ki-ras ) are associated with specific stages of the sporadic, most common types of colorectal tumors