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EPHB2 — TNFSF10

Text-mined interactions from Literome

Tran et al., J Biol Chem 2001 : Activation of the FasR, TNF-R1, and TRAIL-R , respectively, rapidly induced subsequent ERK1/2 activation, an event independent from caspase activity
Milani et al., J Neurochem 2003 (Neuroblastoma) : TRAIL rapidly ( from 20 min ) induced the phosphorylation of Akt and ERK , but not of c-Jun NH2-terminal kinase (JNK)
Mezosi et al., J Clin Endocrinol Metab 2004 : A MAPK kinase inhibitor ( U0126 ) could enhance the cytokine induced sensitization of thyroid cells to TRAIL, reinforcing the inhibitory role of Erk on TRAIL signaling
Zhang et al., Cancer Biol Ther 2004 (Colonic Neoplasms) : TRAIL mediated activation of ERK occurred in both cell lines
Secchiero et al., Cell Mol Life Sci 2004 : Western blot analysis consistently showed that TRAIL induced a significant activation of ERK1/2 , and a much weaker phosphorylation of Akt, while it did not affect the p38/MAPK pathway
Drosopoulos et al., J Biol Chem 2005 (Cell Transformation, Neoplastic...) : We also report a prolonged MEK dependent activation of ERK1/2 and increased c-FOS expression induced by TRAIL in this system
Li et al., Int J Mol Med 2006 (Ovarian Neoplasms) : Simultaneously, silencing of hPEBP4 in CaoV-3 cells enhances TRAIL induced ERK and JNK activation
Lee et al., Biochem Biophys Res Commun 2006 (Breast Neoplasms) : TRAIL mediated activation of ERK and JNK were also observed in parent MDA-231 cells but not in MDA-231/TR cells
Rieger et al., Cell Physiol Biochem 2007 (Glioma) : Apo2L.0 induced the phosphorylation of ERK1/2 , but not of Akt
Vilimanovich et al., Cell Mol Life Sci 2008 (Brain Neoplasms...) : In addition, siRNA inhibition of c-FLIP expression eliminates TRAIL induced ERK1/2 activation and proliferation ... Furthermore, overexpression of c-FLIP ( L ) potentiates TRAIL induced ERK1/2 activation and proliferation of resistant glioma cells ... Our results have shown for the first time that TRAIL induced ERK1/2 activation and proliferation of TRAIL-resistant human glioma cells is dependent upon the expression of the long form of the caspase-8 inhibitor c-FLIP ( L )
Sung et al., J Biol Chem 2010 (Colonic Neoplasms) : ERK1/2 ( but not p38 MAPK or JNK ) activation was also required for gossypol induced TRAIL receptor induction ; gene silencing of ERK abolished both DR5 induction and potentiation of apoptosis by TRAIL