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PDGFB — SMAD3
Text-mined interactions from Literome
Saika et al., Lab Invest 2004
(Disease Models, Animal...) :
Our data show that
induction of
PDGF-BB by
Smad3 dependent TGF-beta signaling is likely an important secondary proliferative component of the disease process
Jinnin et al., Mol Pharmacol 2006
(Scleroderma, Systemic) :
Immunoprecipitation revealed that
SIS3 attenuated the transforming growth factor (TGF)-beta1 induced phosphorylation of Smad3 and interaction of
Smad3 with Smad4 ... Moreover, we demonstrated that
SIS3 completely
diminished the constitutive phosphorylation of
Smad3 as well as the up-regulated type I collagen expression in scleroderma fibroblasts
Li et al., Diabetes 2010
(Diabetes Mellitus, Experimental...) :
Immunoprecipitation/Western blotting showed that
Smad3 was activated by AGEs but was
inhibited by
SIS3 in MMECs and in STZ induced diabetic nephropathy
Kim et al., Cancer Lett 2012
(Breast Neoplasms) :
In addition, EGF induced MMP-9 expression was inhibited by UO126 ( a MEK1/2 inhibitor ) or
SIS3 ( a
smad3 inhibitor ), but not by SP600125 ( a JNK inhibitor )
Inoue et al., Lab Invest 2012
(Fibrosis...) :
Both OCT and
SIS3 , a
Smad3 inhibitor , abrogated the binding of pSmad3 to the promoter and consequently attenuated the autoinduction