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AIM2 — IL1A

Text-mined interactions from Literome

Coll et al., PloS one 2011 (Inflammation) : In murine bone marrow derived macrophages, CRID3 inhibited IL-1ß secretion and caspase 1 processing in response to stimulation of NLRP3 and AIM2 but not NLRC4
Saiga et al., Int Immunol 2012 (Tuberculosis, Pulmonary) : Genomic DNA extracted from M. tuberculosis ( Mtb DNA ) induced caspase-1 activation and IL-1ß/IL-18 secretion in an AIM2 dependent manner
Koo et al., PloS one 2012 (Scrub Typhus) : Furthermore, Orientia stimulated secretion of IL-1ß and activation of caspase-1 are ASC- and caspase-1- dependent since IL-1ß production was impaired in Asc- and caspase-1-deficient macrophages but not in Nlrp3-, Nlrc4- and Aim2-deficient macrophages
Chen et al., EMBO Mol Med 2012 (Inflammation...) : In tumour cells, AIM2 and RIG-I are required for IL-1ß induction by EBV genomic DNA and EBV encoded small RNAs, respectively, while NLRP3 responds to extracellular ATP and reactive oxygen species
Dotson et al., J Biol Chem 2013 (Tularemia) : An enhanced activation of caspase-1 and IL-1ß observed in FTL_0325 mutant infected macrophages at 24 h post-infection was independent of both AIM2 and NLRP3