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IL1A — PRG3

Text-mined interactions from Literome

Yamada et al., J Rheumatol 1999 (Disease Models, Animal...) : In vitro, esculetin inhibited the IL-1alpha induced release of proteoglycan into the medium in a dose dependent manner
Beekman et al., Osteoarthritis Cartilage 1998 : Matrix degradation by chondrocytes cultured in alginate : IL-1 beta induces proteoglycan degradation and proMMP synthesis but does not result in collagen degradation
Wang et al., Zhongguo Yao Li Xue Bao 1998 (Arthritis, Experimental) : Ind 10 mumol.L-1 enhanced the proliferation of rabbit synovial fibroblasts and suppressed the proteoglycan synthesis of articular cartilage in response to IL-1 in vitro
García de Yébenes et al., J Neurochem 1999 (Alzheimer Disease...) : Regulation of the heparan sulfate proteoglycan , perlecan, by injury and interleukin-1alpha
Billinghurst et al., Arthritis Rheum 2000 : IL-1alpha initially induced a decrease in tissue proteoglycan content in nasal cartilage
Bird et al., Equine Vet J 2000 : NO fully mediated the suppressive effect of IL-1 on proteoglycan synthesis
van der Kraan et al., Osteoarthritis Cartilage 2000 (Arthritis, Experimental) : Bone morphogenetic protein-2 (BMP-2) mediated stimulation of articular cartilage proteoglycan ( PG ) synthesis is suppressed in arthritic murine knee joints and by interleukin-1 (IL-1)
Smith et al., Arthritis Rheum 2000 : The effects of growth factor gene transfer on proteoglycan synthesis in the presence of IL-1 were also measured ... IL-1 suppressed proteoglycan synthesis by 50-60 % ... IGF-1 and TGFbeta genes restored proteoglycan synthesis to control levels in the presence of IL-1
Attur et al., J Biol Chem 2000 (Osteoarthritis) : Human chondrocytes that overexpressed IL-1RII were resistant to IL-1 induced IL-1beta mRNA accumulation and inhibition of proteoglycan synthesis
Gassner et al., Int J Oral Maxillofac Surg 2000 : It was concluded that motion in the form of cyclic tensile stretch is a remarkable anti-inflammatory stimulus reversing the IL-1 induced suppression of proteoglycan synthesis in chondrocytes
Tamura et al., Jpn J Pharmacol 2001 : Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha induced proteoglycan degradation in cultured rabbit articular chondrocytes
Sullivan et al., J Orthop Res 2002 : This two-step regimen dramatically inhibited IL-1 stimulated proteoglycan degradation and concomitantly increased latent and active transforming growth factor-beta1 in culture medium
van Beuningen et al., Osteoarthritis Cartilage 2002 : In seven cell lines ( P2, P5, H1, H3, H4, H5, H6 ) high production of type II collagen corresponded with high levels of mRNA of type II collagen ( and prevalence of the IIB type ) and with high IL-1 induced suppression of proteoglycan synthesis
Chowdhury et al., Osteoarthritis Cartilage 2003 (Mechanotransduction, Cellular) : For both cell sub-populations, IL-1 beta inhibited cell proliferation whereas proteoglycan synthesis was not affected
McDonnell et al., Arthritis Rheum 1992 : We used a monoclonal antibody ( MAb ) against leukocyte integrins, which markedly depressed leukocyte accumulation in SF, to evaluate the role of synovial leukocytes on IL-1 induced increases in SF proteoglycan and stromelysin levels
Buttle et al., Biochem J 1992 : The peptidyl diazomethane inactivator of cysteine endopeptidases, benzyloxycarbonyl-Tyr-Ala-CHN2, was tested as an inhibitor of interleukin 1 alpha stimulated release of proteoglycan from bovine nasal septum cartilage explants
Morris et al., Am J Vet Res 1992 : The reduction in control and IL-1 stimulated proteoglycan degradation by hyaluronate had a concentration dependent trend
Niki et al., J Immunol 2004 (Arthritis, Experimental...) : MA-IL-1 expressed on synoviocytes triggered synoviocyte self-proliferation through cell-to-cell ( i.e., juxtacrine ) interactions and also promoted proteoglycan release from the cartilage matrix in chondrocyte monolayer culture
Chandrasekhar et al., Matrix 1992 (Inflammation) : The effect of IL-1 on proteoglycan synthesis was studied after intraarticular injection of IL-1 into the knee joints of rats
Radons et al., Int J Mol Med 2006 : We found an IL-1 induced reduction in the expression of the cartilage specific proteoglycan aggrecan as an indicator for the IL-1 mediated dedifferentiation of chondrocytes ... IL-6 has been found to act synergistically in the IL-1 induced suppression of the proteoglycan synthesis in chondrocytes
Shin et al., Arch Pharm Res 2006 (Osteoarthritis) : LAD103 also showed significant down regulation of PGE2 generation in LPS treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-1alpha induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation
Mbvundula et al., J Pharm Pharmacol 2006 : In this study the mechanisms of action of the synthetic cannabinoid agonists, HU-210 and Win-55,212-2, were studied to determine if they affected interleukin-1 alpha (IL-1alpha) induced proteoglycan and collagen degradation in bovine nasal cartilage explant cultures and prostaglandin E2 ( PGE2 ) production in primary cultures of bovine articular chondrocytes
Matsushita et al., Mod Rheumatol 2004 : We have previously reported that interleukin-1 (IL-1) inhibited proteoglycan ( PG ) synthesis and induced the production of ROS in cartilage explants and isolated chondrocyte cultures
Cernanec et al., J Rheumatol 2007 : In 1 % O2 ( but not in 20 % O2 ), Mn porphyrin significantly inhibited IL-1 induced proteoglycan degradation
Kang et al., Res Commun Mol Pathol Pharmacol 2004 : Ventol also showed significant down regulation of PGE2 generation in LPS treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-1alpha induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation
Studer et al., J Orthop Res 2008 (Disease Models, Animal...) : Blocking p38 MAPK reduced IL-1 induced NO and PGE-2 accumulation and partially restored proteoglycan synthesis
Chabane et al., Osteoarthritis Cartilage 2008 : In the present study, we determined the effect of trichostatin A (TSA) and butyric acid ( BA ), two histone deacetylase (HDAC) inhibitors, on NO and PGE ( 2 ) synthesis, inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 expression, and nuclear factor (NF)-kappaB DNA binding activity, in interleukin-1beta (IL-1) stimulated human OA chondrocytes, and on IL-1 induced proteoglycan degradation in cartilage explants ... TSA and BA also prevented IL-1 induced proteoglycan release from cartilage explants
Arner et al., Arthritis Rheum 1991 : Interleukin-1 (IL-1) stimulates proteoglycan degradation and prostaglandin E2 ( PGE2 ) release and inhibits proteoglycan synthesis by cartilage in organ culture
van Beuningen et al., Arthritis Rheum 1991 (Metabolic Diseases) : IL-1 induced stimulation of proteoglycan degradation was confined to the first 24 hours after injection in both young and old animals, and was only slightly lower in old cartilage than in young ... In old patellar cartilage, IL-1 induced suppression of proteoglycan synthesis appeared to be more prolonged ... Autoradiography showed that the chondrocytes of the medial side of the femorotibial area were most vulnerable to IL-1 induced suppression of proteoglycan synthesis, especially the medial tibial plateau ... As with the patellar cartilage, IL-1 induced suppression of proteoglycan synthesis in this area of articular cartilage was more prolonged in old animals
Pujol et al., J Rheumatol Suppl 1991 (Osteoarthritis) : It was shown that TGF-beta may counteract the effect of IL-1 on synthesis of both collagen and proteoglycan and production of metalloproteases when it is introduced after IL-1, while it does not prevent the effect of the monokine when it is first added to the cultures
Kandel et al., J Rheumatol 1990 : Whereas human purified interleukin 1 (IL-1) ( 20 U/ml ) stimulated collagenase production and inhibited proteoglycan synthesis
Dunn et al., Future Med Chem 2012 (Arthritis, Rheumatoid...) : They have also been shown to prevent IL-1 induced matrix breakdown of collagen and proteoglycan , indicating that cannabinoids may mediate chondroprotective effects
Ikebe et al., Arthritis Rheum 1990 : Muramyl dipeptide, as well as lipopolysaccharide and interleukin-1 alpha , also enhanced the release of 35S-sulfate prelabeled glycosaminoglycan/proteoglycan from the cell layer, which seems to reflect, at least partially, the increasing degradation of glycosaminoglycan/proteoglycan
Nietfeld et al., J Rheumatol 1990 : Our data suggest that an IL-1 induced inhibition of the proteoglycan synthesis, rather than a stimulation of proteoglycan breakdown causes the proteoglycan depletion of the cartilage
Rainsford et al., J Pharm Pharmacol 1989 (Arthritis...) : APZ was shown to be a potent inhibitor of the production of leucocyte superoxide and synovial interleukin-1 (IL-1)-like activity and stimulated articular cartilage proteoglycan synthesis, but was ineffective as an inhibitor of platelet aggregation or IL-1 induced cartilage degradation in-vitro
Arner et al., Agents Actions 1989 : IL-1 also resulted in a dose related decrease in the ability of cartilage to synthesize new proteoglycan as measured by 35S incorporation
Chandrasekhar et al., Biochem Biophys Res Commun 1988 : Transforming growth factor-beta is a potent inhibitor of IL-1 induced protease activity and cartilage proteoglycan degradation
van den Berg et al., Ann Rheum Dis 1988 : IL1 caused enhanced proteoglycan degradation and severe inhibition of chondrocyte synthetic function at a concentration of 3 U/ml ( 100 pg/ml )
Hubbard et al., J Orthop Res 1988 : The response appeared to be chondrocyte dependent, for IL-1 stimulated proteoglycan ( PG ) release from living but not from dead ( frozen thawed ) cartilage
von den Hoff et al., J Rheumatol 1995 : IL-1 ( 10 ng/ml, 2 days ) had no significant effect on total proteoglycan synthesis
Taskiran et al., Biochem Biophys Res Commun 1994 : Treatment of cartilage fragments with L-NG-monomethylarginine ( L-NMA ), a competitive inhibitor of NO synthase, both inhibited NO synthesis in response to IL-1 and CAF and restored proteoglycan synthesis
Ostberg et al., FEBS Lett 1995 : In fibroblasts and smooth muscle cells attached to fibronectin, IL-1 caused a pronounced reduction in proteoglycan synthesis, while no reduction occurred in cells plated on bare plastic
Baragi et al., J Clin Invest 1995 (Osteoarthritis) : The Ad.RSV hIL-1ra treated cartilage samples were resistant to IL1 induced proteoglycan degradation over 10 d of sustained organ culture
Panthou et al., Biochem Mol Biol Int 1994 : Effects of transforming growth factor-beta 1, interleukin-1 alpha and interleukin-6 on rat Sertoli cell proteoglycan synthesis
Hardingham et al., Rev Rhum Ed Fr 1994 : IL-1 alpha , beta and TNF alpha inhibit proteoglycan synthesis and at slightly higher concentration they enhance the rates of matrix degradation
Yocum et al., Arch Biochem Biophys 1995 : Bafilomycin A1 inhibits IL-1 stimulated proteoglycan degradation by chondrocytes without affecting stromelysin synthesis ... Interleukin-1 alpha (IL-1) stimulated the release of degraded proteoglycan from primary cultures of chondrocyte monolayers in a time- and dose dependent fashion ... Under these conditions IL-1 stimulated proteoglycan degradation was inhibited by bafilomycin A1 with an IC50 of < 10 nM in both chondrocyte monolayers and articular cartilage explants
Larbre et al., Clin Exp Rheumatol 1994 (Arthritis) : Female cartilage was more sensitive to IL-1 inhibition of proteoglycan synthesis while the opposite was observed in IL-1 induced proteoglycan loss
van Beuningen et al., Ann Rheum Dis 1994 (Synovitis) : TGF-beta 1 aggravates IL-1 induced knee joint inflammation, but counteracts the deleterious effects of IL-1 on articular cartilage proteoglycan synthesis and content
Garg et al., Biochem Mol Biol Int 1993 (Burns...) : The effect of interleukin (IL)-1 beta on proteoglycan ( PG ) synthesis and secretion, into culture medium by normal human skin and post-burn human normal scar using tissue explants in culture, was investigated
Lazarus et al., Lymphokine Cytokine Res 1993 : IL-1 alpha inhibited IGF-1 stimulated proteoglycan ( PG ) synthesis > 95 % at 20 ng/ml ( p < 0.01 )
Goldberg et al., Agents Actions 1993 : IL-1 ( 0.01-10 ng/ml ) caused a dose dependent release of cell surface proteoglycan into the medium of bovine and rabbit articular chondrocytes
Neidel et al., Agents Actions 1993 : Both effects could be neutralized with a polyclonal anti-IL-1 beta antibody ; however, higher antibody titers were required to block IL-1 effects on proteoglycan synthesis than to neutralize those on proteoglycan release ... Both drugs, however, augmented IL-1 induced inhibition of proteoglycan synthesis ... Our data suggest that the effects of IL-1 on articular cartilage proteoglycan synthesis and proteoglycan breakdown can be regulated independently
da Silva et al., Arthritis Rheum 1993 (Cartilage Diseases...) : Testosterone antagonized the effects of IL-1 on both proteoglycan loss and proteoglycan synthesis
Glazer et al., J Clin Pharmacol 1993 : The effect of the drug also was determined on the IL-1 stimulated release of proteoglycan and neutral metalloproteinase activity from the explants
Chandrasekhar et al., Agents Actions Suppl 1993 : To determine whether the two processes are linked, we studied the influence of growth factors on IL-1 induced neutral protease induction, proteoglycan synthesis inhibition and IL-1 receptor expression
Awbrey et al., Agents Actions Suppl 1993 (Osteoarthritis) : We have previously purified and sequenced A1PI synthesized by human articular cartilage and demonstrated in vitro protection from IL-1 induced proteoglycan ( PG ) degradation at a concentration of 1 mg/ml
van Beuningen et al., Ann Rheum Dis 1993 : With insulin-like growth factor, however, TGF-beta potentiated the ex vivo recovery of IL-1 induced suppression of proteoglycan synthesis ... Analogous to the in vitro effects, TGF-beta injected intraarticularly suppressed IL-1 induced proteoglycan degradation ... Furthermore, TGF-beta injected into the joint counteracted IL-1 induced suppression of proteoglycan synthesis
Yeh et al., J Rheumatol 1995 : IL-4 significantly reduced the cartilage proteoglycan degradation induced by IL-1 alpha, TNF-alpha, TNF-alpha plus IL-1 alpha , or LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Hauselmann et al., Arthritis Rheum 1996 : IL-1 induced more severe inhibition of proteoglycan synthesis and a lower ratio of secreted TIMP-l : stromelysin in chondrocytes from superficial cartilage than those from deeper cartilage
Xu et al., Endocrinology 1996 : In pellet cultures of bovine nasal or articular chondrocytes, 20 ng/ml IL-1 alpha induced a significant degradation of both proteoglycan and type II collagen
Arner et al., Biochem J 1996 : A series of isothiazolones that inhibit pro- ( matrix metallo-proteinase ) ( proMMP ) activation but do not inhibit the active enzyme are effective as cartilage protectants in bovine nasal cartilage organ culture, preventing interleukin-1 (IL-1) induced proteoglycan ( aggrecan ) degradation without affecting its synthesis
Van Lent et al., J Rheumatol 1995 (Arthritis, Experimental...) : To determine the regulating role of interleukin-1 alpha and beta ( IL-1 alpha, beta ) and tumor necrosis factor alpha (TNF-alpha) on inhibition of proteoglycan synthesis and proteoglycan degradation in early immune complex arthritis ( ICA ) in the mouse ... Local production of IL-1 in ICA in knee joints seems directly responsible for inhibition of proteoglycan synthesis
Ridley et al., J Immunol 1997 : In a model of cartilage breakdown, short-term IL-1 stimulated proteoglycan resorption and inhibition of proteoglycan synthesis were unaffected by SB 203580, while longer term collagen breakdown was prevented
Glansbeek et al., Arthritis Rheum 1997 : Bone morphogenetic protein 2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1alpha effects on proteoglycan synthesis and content
Sunic et al., Endocrinology 1998 : The aim of this study was to investigate the effects of IGF-I and IL-1 on IGFBP production by ovine articular chondrocytes ( OAC ) and the roles of these IGFBPs in the regulation of proteoglycan synthesis