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BCL2 — PDLIM7

Text-mined interactions from Literome

Noguchi et al., Br J Haematol 2001 (Lymphoma, T-Cell) : Epstein-Barr virus ( EBV ) -encoded latent membrane protein 1 (LMP-1) is essential for immortalization of B cells by EBV, protects the infected cells from apoptotic cell death and induces Bcl-2 expression ... Suppression of LMP-1 expression by antisense oligodeoxynucleotides ( AS-oligo ) to LMP-1 inhibits proliferation, promotes apoptosis and suppresses Bcl-2 expression in EBV transformed B cells ... These results suggest that proliferation, inhibition of apoptosis and Bcl-2 expression in EBV positive NK cell lymphoma cells are not directly regulated by LMP-1 as in EBV transformed B-cell lines, but are probably mediated through other signal transducing systems
Lee et al., Cancer Lett 2009 (Nasopharyngeal Neoplasms) : We found that LMP-1 diminished the pro-apoptotic activity of Par-4 and negatively regulated Par-4 protein by de novo synthesis ; moreover, although LMP-1 accelerated a Par-4 activator, PKA, we demonstrated that LMP-1 also activated the PI3K/Akt pathway and increased Bcl-2 expression to suppress the activity of Par-4
Li et al., Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2011 (Epstein-Barr Virus Infections...) : The increased expression of Bcl-2 may not be induced by LMP1
Rowe et al., J Virol 1994 : However, it was not possible to ascertain whether Bcl-2 upregulation was a specific consequence of LMP1 expression or an artifact of the selection procedure whereby rare Bcl-2+ cells already present in the starting population might best be able to tolerate the potentially toxic effects of LMP1
Murray et al., Blood 1996 (Herpesviridae Infections...) : One EBV protein, BHRF1, is a homologue of BCL-2, whereas another, the latency membrane protein 1 (LMP-1) , upregulates BCL-2 expression in vitro
Wang et al., Cancer Res 1996 : However, the maximum induction of Bcl-2 by LMP1 takes about 48-72 h
Inoue et al., Nihon rinsho. Japanese journal of clinical medicine 1997 : However, regulation of the Bcl-xL , Cdk4 and 6 and p27kip-1 expression by LMP1 and the molecular mechanism of LMP1 mediated B cell transformation remain to be elucidated
Piché et al., Gene Ther 1998 (Lymphoproliferative Disorders) : LMP1 mediated up-regulation of Bcl-2 is thought to be an important element in this process