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JAK3 — TYK2
Pathways - manually collected, often from reviews:
-
BioCarta stat3 signaling pathway:
Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2)
→
STAT3
(modification, activates)
-
BioCarta stat3 signaling pathway:
Stat3 activating cytokines/cytokine receptor/JAKs/TYK2 complex (JAK2_JAK1_JAK3-TYK2)
→
Cytokine receptor/JAKs/TYK2 complex (TYK2-JAK2_JAK1_JAK3)
(modification, collaborate)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Shang et al., Cancer Sci 2007
(Carcinoma, Renal Cell...) :
The results suggest that the resistance of RCC to IFN-alpha is associated with the lack of Jak1,
Tyk2 and Stat1 expression and defective
Jak-Stat activation , but not with a lack of IFN-alpha receptor, suppressors of cytokine signaling induction or other factors examined
Dedoni et al., J Neurochem 2010
(Neuroblastoma) :
Janus kinase inhibition
reduced IFN-ß stimulated
TyK2 and STAT1 phosphorylation, STAT1 transcriptional activity, induction of double stranded RNA activated protein kinase ( PKR ) and caspase cleavage