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EPHB2 — FXR1

Text-mined interactions from Literome

Zhang et al., Cardiovasc Res 2008 : Upregulation of AT2R appears to play a role in the FXR mediated inhibition of ERK activation via upregulation of Rous sarcoma oncogene (Src) homology domain containing tyrosine phosphatase 1 ( SHP-1 ) because FXR mediated upregulation of SHP-1 can be blocked by an AT2R antagonist and FXR mediated ERK inactivation was significantly attenuated via treatment with either an AT2R antagonist or a SHP-1 inhibitor
Noh et al., Drug Metab Dispos 2011 : Consistently, enforced expression of FXR promoted the phosphorylation of AMPKa, ERK1/2, and C/EBPß, verifying that C/EBPß phosphorylation elicited by CDCA results from the activation of AMPK and ERK1/2 by FXR
Peng et al., PloS one 2012 (Cell Transformation, Neoplastic...) : In stably transfected human colon cancer cells, overexpression of FXR reduced EGFR, ERK , Src phosphorylation and cell proliferation, and in nude mice attenuated the growth of human colon cancer xenografts ( 64 % reduction in tumor volume ; 47 % reduction in tumor weight ; both P < 0.01 )