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EPHB2 — RAD51

Text-mined interactions from Literome

Ko et al., Carcinogenesis 2008 (Carcinoma, Non-Small-Cell Lung...) : Exposure of human non-small lung cancer cells to gefitinib decreased cisplatin- or MMC elicited ERK1/2 activation and Rad51 protein induction ... Enhancement of ERK1/2 signaling by constitutively active mitogen activated protein kinase kinase 1/2 ( MKK1/2-CA ) increased Rad51 protein levels and protein stability in gefitinib and cisplatin or MMC cotreated cells
Ko et al., Mol Cancer Res 2009 (Carcinoma, Non-Small-Cell Lung...) : Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells ... In this study, we investigated the roles of ERK1/2 and AKT signaling pathways in regulating Rad51 expression and cytotoxic effects in different NSCLC cell lines treated with erlotinib ... Blocking the activations of ERK1/2 and AKT by MKK1/2 inhibitor ( U0126 ) and phosphoinositide 3-kinase inhibitor ( wortmannin ) suppressed the expression of Rad51 and enhanced the erlotinib induced cell death in erlotinib-resistant cells
Ko et al., Toxicol Appl Pharmacol 2011 (Carcinoma, Non-Small-Cell Lung...) : Curcumin enhances the mitomycin C-induced cytotoxicity via downregulation of MKK1/2-ERK1/2 mediated Rad51 expression in non-small cell lung cancer cells ... Enhancement of ERK1/2 activation by constitutively active MKK1/2 ( MKK1/2-CA ) increased Rad51 protein levels in curcumin and MMC co-treated human lung cells
Ko et al., Regul Toxicol Pharmacol 2012 (Carcinoma, Non-Small-Cell Lung...) : In contrast, enhanced ERK1/2 activation by the constitutively active MKK1/2 ( MKK1/2-CA ) vector significantly restored the 17-AAG reduced Rad51 protein levels and cell viability