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MIF — PTGS2

Text-mined interactions from Literome

Sampey et al., Arthritis Rheum 2001 (Arthritis, Rheumatoid) : Regulation of synoviocyte phospholipase A2 and cyclooxygenase 2 by macrophage migration inhibitory factor
Meyer-Siegler et al., Mol Med 2001 (Prostatic Neoplasms) : COX-2 specific inhibitor, NS-398, increases macrophage migration inhibitory factor expression and induces neuroendocrine differentiation in C4-2b prostate cancer cells
Santos et al., J Rheumatol 2004 (Arthritis, Rheumatoid) : MIF significantly induced COX-2 and IL-6 protein and mRNA expression as well as PGE ( 2 ) and IL-8 production ... Antagonism of p38 MAP kinase inhibited MIF induction of COX-2 , PGE ( 2 ), and IL-6 ... MIF activates RA FLS COX-2 and IL-6 expression via p38 MAP kinase activation and induces IL-8 via p38 and ERK MAP kinase independent pathways
Hayashi et al., J Invest Dermatol 2006 (Keloid) : We found that MIF enhanced cyclooxygenase-2 activity in NF more than in KF
Carli et al., Endocrinology 2009 (Endometriosis) : These findings show for the first time a direct role for MIF in the up-regulation of COX-2 synthesis and PGE ( 2 ) secretion in ectopic endometrial cells
Xin et al., Mol Cancer Res 2010 (Colorectal Neoplasms) : Several studies have shown an important contributing role for MIF dependent COX-2 expression in the progression of these disorders
Gesser et al., Inflamm Res 2011 (Psoriasis) : The effects of DMF on the MIF induced activation of MSK1, RSK1, cAMP-responsive element binding protein ( CREB ), Cox-2 and c-Jun, JunB and p53 were studied by Western blotting using phospho-specific antibodies