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Bai et al., Cell Metab 2011
(Glucose Intolerance...) :
PARP-2 regulates SIRT1 expression and whole-body energy expenditure ... Our results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes
Bai et al., Cell Metab 2011
:
Also, the pharmacologic inhibition of PARP in vitro and in vivo increased NAD ( + ) content and SIRT1 activity and enhanced oxidative metabolism
Massudi et al., PloS one 2012
:
Age associated increases in oxidative nuclear damage have been associated with PARP mediated NAD ( + ) depletion and loss of SIRT1 activity in rodents