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FOS — VEGFA

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: FOS → FIGF/PGF/VEGFA/VEGFB/VEGFC (gene expression, expression)
  

Text-mined interactions from Literome

Marumo et al., Diabetes 1999 : Binding activity of transcription factor AP-1 , which is suggested to regulate induction of the MCP-1 gene together with NF-kappaB, was also stimulated by VEGF ... PD 98059 inhibited the VEGF induced activation of AP-1
Hossain et al., J Biol Chem 2000 : Transfection of cells with a c-jun dominant negative effectively inhibited both AP-1 activation and VEGF mRNA induction by lead
Bancroft et al., Clin Cancer Res 2001 (Carcinoma, Squamous Cell...) : Expression of IL-8 and VEGF in the cell lines was associated with coactivation of both NF-kappaB and AP-1, and U0126 inhibited both NF-kappaB and AP-1 reporter activity in UM-SCC-9 and UM-SCC-11B cells
Hu et al., J Natl Cancer Inst 2001 (Ovarian Neoplasms) : Forced overexpression of c-Jun and c-Fos in OVCAR-3 cells stimulated VEGF promoter activity fourfold
Shih et al., Growth Factors 2001 : Role of AP-1 and HIF-1 transcription factors in TGF-beta activation of VEGF expression ... The tyrosine kinase inhibitor genistein and AP-1 inhibitor curcumin significantly blocked TGF-beta induction of VEGF expression while SP-1 and MKK1 inhibitors did not
Hu et al., Zhonghua Yi Xue Za Zhi 2001 : Triptolide might inhibit VEGF expression and production by interfering with transcription factor AP-1 formation
Hoshi et al., Biochem Biophys Res Commun 2002 : High glucose and the PKC stimulator, phorbol 12-myristate 13-acetate ( PMA ) induced activator protein-1 (AP-1) dependent transcriptional activity and expression of VEGF
Urata et al., Free Radic Biol Med 2002 : Promoter assay showed that the induction of VEGF was dependent on AP-1 ... The activity of Ras/Raf-1/MEK/ERK1/2 was involved in the CML-BSA stimulated signaling pathways to activate the AP-1 transcription with a peak at 1 h. AGE-BSA also induced VEGF mediated by AP-1 , however, there was a difference of effect between AGE-BSA and CML-BSA in the activation of AP-1
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : Recombinant EGF induced EGFR phosphorylation, activation of NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Cho et al., Arthritis Rheum 2002 : CSA may exert an antiangiogenic effect by inhibiting AP-1 mediated VEGF expression in rheumatoid synovial fibroblasts
Burroughs et al., Mol Cancer Res 2003 (MAP Kinase Signaling System) : The expression of an activator protein (AP)-1 dominant negative in an immortalized prostate epithelial cell line PZ-HPV-7 suppressed the IGF-I induced increase in VEGF promoter activity
Holmes et al., FEBS Lett 2004 : These findings show for the first time that VEGF and PlGF induce mRNA expression of the transcription factors FosB and c-Fos , and suggest that these factors may play a role in the biological responses mediated by PlGF and Flt-1
Pufe et al., J Pathol 2004 (Osteoarthritis) : VEGF stimulation induced receptor phosphorylation, activation of the mitogen activated protein kinases ERK 1/2, and long lasting activation of the transcription factor AP-1 ( activator protein-1 )
Grau et al., Cancer Res 2004 (Colonic Neoplasms) : This cyclopentenone was able to inhibit activator protein1 (AP-1) dependent transcriptional induction of COX-2 and VEGF promoters induced by phorbol 12-myristate 13-acetate ( PMA ) or c-Jun overexpression
Stanley et al., Biochem Biophys Res Commun 2005 (Neovascularization, Pathologic...) : These effects are caused by the inhibition of constitutively active AP-1 in prostate cancer cells, resulting in the down-regulation of secretion of VEGF and TGF-beta1 from PC-3 cells
Chang et al., Int J Oncol 2006 (Neoplasms...) : Extracellular signal regulated kinases and AP-1 mediate the up-regulation of vascular endothelial growth factor by PDGF in human vascular smooth muscle cells ... Transient transfection studies using an AP-1 decoy oligonucleotide confirmed that the activation of AP-1 is involved in PDGF induced VEGF upregulation ... The above results suggest that ERK-1/2 and AP-1 signaling pathways are involved in the PDGF induced VEGF expression in human VSMCs and that these paracrine signaling pathways induce endothelial cell proliferation
Lee et al., J Biomed Sci 2006 : Hyperbaric oxygen induces VEGF expression through ERK, JNK and c-Jun/AP-1 activation in human umbilical vein endothelial cells
Park et al., Int J Oncol 2006 : EGCG were found to inhibit dose-dependently the VEGF expression and activation of PDGF receptor, Erk-1/2 and AP-1 induced by PDGF
von Metzler et al., Leukemia 2007 (Bone Resorption...) : The AP-1 blockade contributed to significant reduction of osteoclastic vascular endothelial growth factor production
Kim et al., Biochem Biophys Res Commun 2008 (Breast Neoplasms) : VEGF reporter gene activity was significantly inhibited by either hypoxia-inducible factor-alpha ( HIF-1alpha ) siRNA or AP-1 decoy ODN
Chuang et al., Chem Biol Interact 2010 : Thus, the present results indicate that R in combination with VE attenuates VEGF expression in HL-60 cells and that this effect is mediated by a decreased binding activity of AP-1 through down-regulation of protein expression of insulin-like growth factor 1 receptor ( IGF1-R ) /IRS-1, while the antioxidant activity of R+VE appears to play a minor role
Tripathi et al., Mol Cell Biochem 2012 (MAP Kinase Signaling System...) : Gel shift assays demonstrated that ANP inhibited VEGF stimulated AP-1 and CREB DNA binding ability by 67 and 62 %, respectively ... The addition of the protein kinase G ( PKG ) inhibitor, KT-5823, restored the VEGF stimulated activation of MAPKs, AP-1 , and CREB, demonstrating the integral role of cGMP/PKG signaling in NPRA mediated effects
Finkenzeller et al., Biochem Biophys Res Commun 1995 : In this study, we investigated the functional role of the transcription factor AP-1 in hypoxia induced expression of the vascular endothelial growth factor ( VEGF ) by using dexamethasone as an inhibitor of AP-1 activity ... These results indicate that hypoxia induced VEGF expression is independent of AP-1 mediated transcription
Tsurumi et al., Nat Med 1997 : In contrast, nitric oxide ( NO ) donors inhibit PKC induced VEGF upregulation by interfering with binding of the transcription factor activator protein-1 (AP-1) to the VEGF promoter