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IL5 — LTB
Text-mined interactions from Literome
Rola-Pleszczynski et al., Union Med Can 1989
:
In particular,
LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma,
stimulate the production of
interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus infected or tumor target cells
Matsumoto et al., Prostaglandins Leukot Essent Fatty Acids 1995
(Leukemia, Basophilic, Acute) :
IL-3 and
IL-5 enhance the production of
LTB4 stimulated by calcium ionophore in rat basophilic leukemia cells ... These results suggest that IL-3 and
IL-5 increase the production of
LTB4 by priming the activity of phospholipase A2(PLA2) without inducing enzymes in the arachidonate 5-lipoxygenase pathway
Yamaoka et al., Eur J Immunol 1993
:
In this study, we investigated whether
LTB4 regulates
IL-5 generation from human T cells and subsequently modulates eosinophil functions ... Preincubation of T cells with very low concentrations ( 10 ( -12 ) to 10 ( -8 ) M ) of
LTB4 induced concentration dependent
IL-5 production, the event occurring after the first 24 h of cultivation ... These data suggest that
LTB4 induces bioactive
IL-5 production from T cells and that the released IL-5 modulates eosinophil functions which might play a crucial role in eosinophil linked allergic inflammatory process