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HDAC1 — IL1B
Text-mined interactions from Literome
Carta et al., Blood 2006
(Calcium Signaling) :
In the present study, we investigated the
effects of 2
HDAC inhibitors on
IL-1beta secretion : suberoylanilide hydroxamic acid and a newly developed hydroxamic acid derived compound ITF2357 ... These
HDAC inhibitors do not
affect the synthesis or intracellular localization of
IL-1beta but both strongly reduce the levels of extracellular IL-1beta by preventing the exocytosis of IL-1beta containing secretory lysosomes
Yoshikawa et al., Arch Otolaryngol Head Neck Surg 2006
(Cholesteatoma, Middle Ear) :
The messenger RNA expressions of
LARC ( liver and activation regulated chemokine ), GMCSF ( granulocyte-macrophage colony stimulating factor ), epiregulin, ICAM1 ( intercellular adhesion molecule 1 ), and TGFA ( transforming growth factor alpha ) were more strongly
up-regulated by IL-1alpha and/or
IL-1beta in MECF than in SF, suggesting that these fibroblasts derived from different tissues retained their typical gene expression profiles
Wang et al., Growth Factors 2009
:
To investigate the functional involvement of HDACs in the signaling pathway of FGF2 and IL-1beta, we examined the
effects of
HDAC inhibition on activities of FGF2 or
IL-1beta on gene expression of MMP-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-5 ( ADAMTS5 ), collagen type II, and aggrecan