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IL1B — SMC4

Text-mined interactions from Literome

Gray et al., J Cardiovasc Pharmacol 1999 (Coronary Disease) : We also demonstrated that suramin causes cell-surface accumulation of the elastin binding protein, a receptor that not only anchors SMCs to the extracellular matrix, but also inhibits SMC response to interleukin-1beta (IL-1beta)
Cai et al., J Steroid Biochem Mol Biol 2001 : Stimulation of SMC with IL-1beta or TNFalpha led to a time- and dose dependent increase of mRNA levels for 11beta-HSD1, while 11beta-HSD2 mRNA levels decreased
Knipp et al., J Surg Res 2004 : Treatment of interleukin-1beta stimulated RA-SMC with aminoguanidine led to an increase of 96 % in MMP-9 activity ( P = 0.003 ) by gelatin zymography, a 40 % increase in pro-MMP-9 protein ( P = 0.018 ) by Western blot, and a 155 % increase in MMP-9 mRNA ( P = 0.06 ) by reverse transcription polymerase chain reaction
Izikki et al., J Pharmacol Exp Ther 2009 (Anoxia...) : Treatment of human PA-SMCs with roflumilast N-oxide, the active metabolite of roflumilast, at concentrations up to 10 ( -6 ) M, potentiated PA-SMC growth inhibition induced by prostacyclin ( 10 ( -6 ) M ) or interleukin-1beta ( 10 ng x ml(-1) ) but was inactive on its own
Durante et al., Thromb Res 1994 : The addition of cGMP derivatives modestly increased IL-1 beta induced SMC nitrite generation without affecting the production of iNOS mRNA
Molossi et al., J Cell Physiol 1995 : Thus, our studies suggest that vascular SMC fibronectin synthesis is regulated by reciprocal induction of IL-1 beta and TNF-alpha activity and provide the first demonstration of a ` cytokine loop ' modulating matrix production
Zou et al., Prostaglandins Leukot Essent Fatty Acids 1997 : Stimulation of SMC with interleukin-1 beta (IL-1 beta) resulted in production of cyclooxygenase metabolites ( e.g. 6-keto-PGF1 alpha, PGE2, PGF2 alpha, PGD2 ), 15-, 11-, 5-HETE, and free AA1 with a coincident decline of phosphatidylcholine ( PC ) in SMC ... Furthermore, TXB2 was produced in large quantities during co-incubation of IL-1 beta stimulated SMC with human platelets for 30 min in concert with a significant decrease of 6-keto-PGF1 alpha and eicosanoids ( PGE2, PGF2 alpha and PGD2 ) compared with control ( P < 0.01 )
Schönbeck et al., J Biol Chem 1997 : Stimulation of vascular SMC and EC through rCD40L resulted in the release of biologically active IL-1beta , indicating processing of the native IL-1beta precursor induced by the ligand