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ACAN — IGF1
Text-mined interactions from Literome
Wang et al., Arthritis Rheum 2003
:
The
effects of
IGF-1 on the expression of IGF-1, IL-1alpha, and IL-1beta and their respective receptor systems, the
aggrecan core protein, and CII were determined by flow cytometry
Curtis et al., Biochem J 1992
:
This suggests that
aggrecan synthesis is
stimulated by
IGF-I at the level of translation of mRNA coding for the core protein of this proteoglycan and that other growth factors are present in serum that stimulate aggrecan synthesis at the level of transcription of the core-protein gene
Darling et al., Cell Tissue Res 2005
:
IGF-I increased
aggrecan gene expression for the same groups
Fernandez-Cancio et al., Growth Horm IGF Res 2008
:
IGF-I stimulated IGF-I, IGFBP3, SOX9, COL2A1 and
aggrecan expression whereas it inhibited IGF-IR expression
Fernández-Cancio et al., Growth Horm IGF Res 2009
:
IGF-I stimulated IGF-I, IGFBP-3, SOX9, COL2A1 and
aggrecan expression and opposed COL2A1 and aggrecan gene expression inhibition by VitD
Wheeler et al., Osteoarthritis Cartilage 2009
:
IGF-1 alone
stimulated gene expression of
aggrecan and collagen II, but simultaneous 24h compression suppressed this effect ... While
aggrecan synthesis was transcriptionally
regulated by
IGF-1 , inhibition of aggrecan synthesis by sustained compression appeared post-transcriptionally regulated
Koshimizu et al., J Biol Chem 2012
:
Knockdown of vinculin in the metatarsal organ culture abrogated the IGF-I induced growth and inhibited the
up-regulation of Col2a1 and
aggrecan expression by
IGF-I
Chandrasekhar et al., Agents Actions Suppl 1993
:
Finally, with respect to proteoglycan synthesis, TGF-beta, PDGF and
IGF-1 reversed IL-1
induced PG suppression to different extents, while FGF slightly potentiated IL-1 induced suppression of
aggrecan synthesis
Yaeger et al., Exp Cell Res 1997
:
Neither
IGF-I nor insulin nor transforming growth factor beta ( TGF-beta ) alone
stimulated induction of
aggrecan or type II collagen production by dedifferentiated AHAC