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AREG — EGF

Text-mined interactions from Literome

Sørensen et al., J Lab Clin Med 2000 : Furthermore, activation of the EGF system in these cells by stimulation with HB-EGF or EGF in mitogenic doses causes a selective increase in the expression of amphiregulin and HB-EGF mRNA ( more than 15-fold and 25-fold, respectively ), whereas there is no increase in the expression of mRNA for the other growth factors or receptors
Ebert et al., J Cancer Res Clin Oncol 2001 (Pancreatic Neoplasms) : These findings suggest that D-type cyclins are differentially expressed in pancreatic cancer and that the aberrant activation of the EGF receptor in human pancreatic cancer by amphiregulin may lead to the progression of the cell cycle via induction of cyclin D3 expression, thus contributing to the growth advantage of these transformed cells
Gielen et al., J Soc Gynecol Investig 2005 (Endometrial Neoplasms) : Next it was shown that amphiregulin indeed could stimulate EGF receptor signaling in ECC-1 cells
Inatomi et al., Int J Mol Med 2006 : Among the various cytokines and growth factors, interleukin-1beta, tumor necrosis factor-alpha, and EGF strongly induced amphiregulin and epiregulin mRNA expression
Xie et al., Proc Natl Acad Sci U S A 2007 : The observation of normal induction of uterine amphiregulin surrounding the blastocyst at the time of attachment in these conditional mutant mice suggests a compensatory role of amphiregulin for uterine loss of HB-EGF , preventing complete failure of pregnancy
Choi et al., J Invest Dermatol 1997 (Psoriasis) : We conclude : ( i ) the mitogenic signaling pathway ( s ) regulating S6 kinase is activated in psoriatic lesions, thus accounting for increased S6 kinase activity in the absence of increased S6 kinase gene or protein expression ; ( ii ) S6 kinase activation in lesional keratinocytes likely occurs in response to EGF receptor stimulation by TGF-alpha and/or amphiregulin , which are known to be elevated in psoriatic lesions ; and ( iii ) keratinocyte as well as T-cell mitogenic signaling pathways are susceptible to inhibition by rapamycin, suggesting that rapamycin may be of therapeutic benefit in the treatment of psoriasis