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CXCL12 — ITGA4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of FN1-ITGA4-ITGB1 → CXCL12 (increases) Robledo et al., J Biol Chem 2001*
  Evidence: Furthermore, the chemokine SDF-1alpha, the ligand of CXCR4, triggered modulation of beta(1) integrin-dependent melanoma cell adhesion to fibronectin.
• OpenBEL Selventa BEL large corpus: Complex of ITGA4-ITGB1 → CXCL12 (increases, CXCL12 Activity)
  Evidence: SDF-1? triggered a transient regulation of adhesion mediated by LFA-1 and ?4?1, and a rapid increase in LFA-1 affinity for soluble ICAM-1, which was inhibited by D12 but not N17 H-Ras.

Text-mined interactions from Literome

DiVietro et al., J Immunol 2007 : Immobilized stromal cell derived factor-1alpha triggers rapid VLA-4 affinity increases to stabilize lymphocyte tethers on VCAM-1 and subsequently initiate firm adhesion
Ngo et al., Blood 2008 (MAP Kinase Signaling System...) : To further investigate the mechanisms of CXCR4 dependent adhesion, we showed that CXCR4 and VLA-4 directly interact in response to SDF-1 , we further investigated downstream signaling pathways regulating migration and adhesion in WM. Together, these studies demonstrate that the CXCR4/SDF-1 axis interacts with VLA-4 in regulating migration and adhesion of WM cells in the bone marrow microenvironment