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Barrios-Rodiles et al., J Immunol 1999 : Interestingly, in the presence of LPS or exogenous IL-1 beta, COX-2 transcripts were stabilized, and actinomycin D inhibited their degradation
Chen et al., Immunology 1999 : In parallel, LPS induction of inducible NO synthase (iNOS) and cyclo-oxygenase-2 (COX-2) proteins and their steady-state levels of mRNA were reduced by SB 203580
Lo et al., J Surg Res 1999 : This study was designed to investigate the effects of eicosapentaenoic acid ( EPA ), a major component of fish oil, on macrophage ( Mphi ) cyclooxygenase (COX) gene expression induced by LPS ... In comparison, COX-1 mRNA expression was not affected by either LPS stimulation or EPA incubation
Fiebich et al., Neuropharmacology 2000 : We investigated the inhibitory effect of paracetamol and caffeine on lipopolysaccharide (LPS) induced cyclooxygenase (COX)- and prostaglandin ( PG ) E ( 2 ) -synthesis in primary rat microglial cells and compared it with the effect of acetylsalicylic acid, salicylic acid, and dipyrone
Berg et al., J Immunol 2001 : To study the role of IL-10 in the regulation of PG production during the acute inflammatory response, we evaluated LPS induced cyclooxygenase (COX) expression and PG production in wild-type ( wt ) and IL-10 ( -/- ) mice
Hori et al., Am J Physiol Gastrointest Liver Physiol 2001 : We investigated the effect of lipopolysaccharide (LPS) on the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in muscularis resident macrophages of rat intestine in situ
Chen et al., Biochem Pharmacol 2001 : We previously reported that oroxylin A, a polyphenolic compound, was a potent inhibitor of lipopolysaccharide (LPS) induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
Ogawa et al., Pediatr Nephrol 2001 : We also examined age related changes in COX mRNA expression induced by lipopolysaccharide (LPS)
Schmid et al., Kidney Int 2001 (Hemolytic-Uremic Syndrome) : Both Stx1 and LPS stimulated COX activity ; however, these effects were not additive
Simonin et al., Am J Physiol Cell Physiol 2002 : 15-Deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) ( 15d-PGJ ( 2 ) ) dose-dependently decreased LPS induced cyclooxygenase (COX)-2 ( -80 % ) and inducible nitric oxide synthase (iNOS) mRNA expression ( -80 % ), whereas troglitazone ( 10 microM ) only inhibited iNOS mRNA expression ( -50 % ). 15d-PGJ ( 2 ) decreased LPS induced interleukin (IL)-1 beta ( -25 % ) and tumor necrosis factor (TNF)-alpha ( -40 % ) expression
Zamamiri-Davis et al., Free Radic Biol Med 2002 : In comparison, COX-1 protein expression was not affected by either LPS stimulation or Se status
Zhang et al., J Endotoxin Res 2002 : The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS induced cyclooxygenase-2 (COX-2) expression in vivo and in vitro
Ban et al., Planta Med 2003 : It also inhibited the LPS induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase ( mPGES )
Lee et al., Mol Cells 2003 : Lipopolysaccharide (LPS) enhances the expression of cyclooxygenase 2 (COX-2) in macrophages, and stimulates production of prostaglandins that cause endothelial dysfunction in septic shock
Shibata et al., J Neurochem 2003 : SB203580 also suppressed expression of iNOS and cyclooxygenase-2 (COX-2) induced by IFN-gamma/LPS
Sakata et al., Cancer Lett 2003 : We designed to investigate the inhibitory effect of hesperidin on lipopolysaccharide (LPS) induced over-expression of cyclooxygenase-2 (COX-2) , inducible nitric oxide synthase (iNOS) proteins, over production of prostaglandin E2 ( PGE2 ) and nitric oxide ( NO ) using mouse macrophage cells
Kim et al., Arch Pharm Res 2003 (Edema) : APW also showed a significant inhibitory effect in LPS induced PGE2 production and cyclooxygenase-2 (COX-2) expression
Ho et al., Br J Pharmacol 2004 (Inflammation) : Accompanying inhibition of LPS induced iNOS, cyclooxygenase-2 (COX-2) , and pro-TNF-alpha proteins was observed
Liu et al., J Surg Res 2004 (Colonic Neoplasms) : In addition, COX-2 mRNA expression and COX-2 protein induced by LPS were also reduced by levamisole
Ribeiro et al., Neuroimmunomodulation 2004 (Embryo Loss...) : To study the effect of LPS and to characterize the isoenzymes involved in the process, specific inhibitors of iNOS ( aminoguanidine ) and COX-II ( meloxicam, nimesulide ) and non-specific of COX ( indomethacin ) were injected intraperitoneally to determine their effect on NO and PG production, and on NOS and COX expression induced by LPS in estrogenized rat uterus
Han et al., Life Sci 2004 : The studies showed that ABL not only inhibited LPS/IFN-gamma mediated nitric oxide ( NO ) production and inducible nitric synthase ( iNOS ) expression, but also decreased LPS/IFN-gamma induced prostaglandin E2 ( PGE2 ) production and cyclo-oxygenase-2 (COX-2) expression in a concentration dependent manner
Kim et al., FEBS Lett 2004 : Kahweol and cafestol significantly suppressed the LPS induced production of prostaglandin E ( 2 ), COX-2 protein and mRNA expression, and COX-2 promoter activity in a dose dependent manner
Peng et al., FASEB J 2005 : In response to LPS , COX-2 expression and PGE2 production increased by two- to four-fold, which were completely blocked by a selective COX-2 inhibitor NS398
Tsukamoto et al., Prostaglandins Other Lipid Mediat 2004 : We revealed that cyclooxygenase (COX)-2 was clearly induced by 9cRA in the presence of LPS
Kis et al., Am J Physiol Regul Integr Comp Physiol 2005 : LPS stimulation increased the expression of COX-2 but not COX-1 or COX-3
Murakami et al., Arch Biochem Biophys 2005 : Thus, we further synthesized dehydrodiisoeugenol and alpha-diisoeugenol from isoeugenols, and investigated whether these dimers could inhibit LPS stimulated nuclear factor kappa B (NF-kappaB) activation and cyclooxygenase (COX)-2 gene expression, both of which are closely involved in inflammation and mutagenesis
Won et al., Glia 2005 : In contrast to LO, however, the cyclooxygenase (COX) may not be involved in the regulation of LPS mediated induction of iNOS gene because COX inhibition by indomethacin ( general COX inhibitor ), SC560 ( COX-1 inhibitor ), and NS398 ( COX-2 inhibitor ) affected neither the LPS induced iNOS expression nor activation of NFkappaB
Akundi et al., Glia 2005 (Encephalitis...) : Here we show that LPS induces cyclooxygenase (COX) 2 by activating sphingomyelinases leading to the release of ceramides, which in turn, activate the p38 mitogen activated protein kinases ( MAPK ), but not the p42/44 MAPK
Zhang et al., J Gastroenterol Hepatol 2005 : In the present study the effects of interleukin (IL)-17 and lipopolysaccharides (LPS) on cyclooxygenase (COX) expression in colonic SEMF were investigated
Shie et al., Glia 2005 (Gliosis...) : We demonstrated that microglial EP2 was necessary for lipopolysaccharide (LPS) activated microglia mediated neurotoxicity, as well as induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2)
Norata et al., J Intern Med 2005 (Carotid Stenosis) : Furthermore, we investigated whether monocyte from D299G to T399I subjects present a defective response to CD40, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, cyclo-oxygenase (COX)-2 and PTX3 expression induced by lipopolysaccharide (LPS)
Smolinski et al., Journal of inflammation (London, England) 2005 : The objective of this study was to test the hypothesis that parthenolide suppresses lipopolysaccharide (LPS) induced serum ( interleukin ) IL-6, tumor necrosis factor (TNF)-alpha, IL-1beta and cyclooxygenase (COX)-2 expression in mice as indicated by reduced splenic and liver mRNA levels
Okada et al., Anticancer Res 2005 : The regulatory effects of eugenol related compounds on lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 cells were investigated by Northern blot analysis
Lu et al., J Immunol 2005 : Addition of H ( 2 ) O ( 2 ) to LPS activated monocytes, but not naive monocytes, caused a significant enhancement of the LPS induced production of MMP-1, COX-2 , and PGE ( 2 )
Gauthier et al., Bioorg Med Chem 2006 : In human blood, COX-2 expression was then induced by LPS , and the inhibitory potency of these drugs was disappointing
Hwang et al., Biotechnol Lett 2005 : LPS increased mRNA transcription of cyclooxygenase (COX)-2 , interleukin (IL)-1beta and inducible nitric oxide synthase (iNOS)
Murakami et al., In Vivo 2005 : Dehydrodiisoeugenol and ferulic acid dimer ( bis-FA ), but not the parent monomers isoeugenol and ferulic acid, inhibit lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 cells
Murakami et al., J Nutr 2005 (Neoplasms) : In the present study, we explored the suppressive activities of 1'-acetoxychavicol acetate ( ACA ), auraptene, nobiletin, and zerumbone toward LPS induced cyclooxygenase (COX)-2 mRNA expression in mouse macrophages and the underlying molecular mechanisms
Zhang et al., J Neuroimmunol 2006 : Cyclooxygenase (COX)-2 and membrane bound prostaglandin E synthase-1 ( mPGES-1 ) were induced by treatment with lipopolysaccharide (LPS) but not with PS liposomes
Smyth et al., Immunology 2006 : We transfected RAW264.7 murine macrophage-like cell lines to over-express constitutively ANXA1 and investigated whether this protein modulates the induction of iNOS, cyclooxygenase-2 (COX-2) and tumour necrosis factor-alpha (TNF-alpha) in response to LPS
Hou et al., J Agric Food Chem 2006 : The anti-inflammatory effect of CL-bromelain was correlated with reduced LPS induced NF-kappaB activity and cyclooxygenase 2 (COX-2) mRNA expression in rat livers
Park et al., Biol Pharm Bull 2006 : These results suggest that GBB inhibits LPS induced iNOS, COX-2 and TNF-alpha expressions through the down-regulation of NF-kappaB-DNA binding activity
Li et al., Biomed Res 2006 (Inflammation) : LPS dependent expression of cyclooxygenase-2 (COX-2) protein was also inhibited markedly by isoeugenol, and less effectively by eugenol
Woo et al., Immunobiology 2006 : In the present study, baicalein and baicalin, a flavonoid present in the root of Scutellaria baicalensis Georgi, were examined for their effects on LPS induced cyclooxygenase-2 (COX-2) gene expression in Raw 264.7 macrophages
Wu et al., J Ethnopharmacol 2006 : SCEPP-5 at 30 microg/ml remarkably blocked the LPS induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression
Jang et al., J Med Food 2006 : The aqueous extract of P. grandiflorum was shown to suppress PGE ( 2 ) synthesis and NO production by inhibiting LPS stimulated cyclooxygenase (COX)-2 activity and expression of inducible NO synthase (iNOS) mRNAs
Lee et al., Neurosci Res 2006 : SG ( 10-100 microg/ml ) inhibited LPS induced generation of nitric oxide ( NO ) and reactive oxygen species ( ROS ), as well as inhibited LPS induced cytosolic phospholipase A2 (cPLA2), cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) expression dose-dependently
Reddy et al., Arch Pharm Res 2006 : Artemisolide inhibited LPS induced PGE2 and NO production with IC50 values of 8.7 microM and 6.4 microM, respectively, but also suppressed LPS induced synthesis of cyclooxygenase (COX)-2 or inducible NO synthase (iNOS)
Yun et al., Biol Pharm Bull 2007 : Taken together, our data indicate that styraxoside A inhibits LPS induced iNOS, COX-2 , TNF-alpha, and IL-1beta expressions through the down-regulation of NF-kappaB-DNA binding activity
Kamachi et al., J Pharmacol Exp Ther 2007 (Inflammation) : They also reduced the LPS induced release of arachidonic acid from membrane phospholipids at 4 h and the LPS induced increase in the level of cyclooxygenase (COX)-2 protein at 6 h, but not the level of COX-2 mRNA at 3 h
Yang et al., Neurol Res 2007 : The effects of amygdalin extracted from Armeniacae semen on the LPS stimulated mRNA expressions of cyclooxygenase (COX)-1 , COX-2 and inducible nitric oxide synthase (iNOS) in the mouse BV2 microglial cells were investigated using 3- ( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyltetrazolium bromide ( MTT ) assay, reverse transcription-polymerase chain reaction ( RT-PCR )
Hooshmand et al., J Nutr Biochem 2007 : To test the latter part of our hypothesis, we explored the role of genistein, a naturally occurring SERM with high affinity to bind ERbeta, in inhibiting the lipopolysaccharide (LPS) stimulated cyclooxygenase (COX)-2 in chondrocytes
Kim et al., Vascul Pharmacol 2007 : Polygonum cuspidatum water extract ( PCWE ) was shown to be a potent inhibitor of lipopolysaccharide (LPS) induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
Caruso et al., Endocrinology 2007 (Inflammation) : alpha-MSH ( 5 microm ) reduced the nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) induced by bacterial lipopolysaccharide ( LPS, 1 microg/ml ) plus interferon-gamma ( IFN-gamma, 50 ng/ml ) in cultured astrocytes after 24 h. alpha-MSH also attenuated the stimulatory effect of LPS/IFN-gamma on prostaglandin E ( 2 ) release and cyclooxygenase-2 (COX-2) expression
Kuo et al., J Cell Biochem 2008 (Inflammation) : In this study, we have demonstrated that 5-aminoimidazole-4-carboxamide riboside ( AICAR ), an activator of AMPK, inhibited lipopolysaccharide (LPS) induced protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in macrophages and microglial cells at the gene transcription level
Li et al., Bioorg Med Chem Lett 2007 : Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage
Shen et al., J Mol Cell Cardiol 2007 : Lipopolysaccharide (LPS) induces cyclooxygenase-2 (COX-2) expression in cardiomyocytes, which plays a role in myocardial depression during endotoxemia
Bawolak et al., Regul Pept 2008 : LPS ( 100 microg/kg i.v. ) induced the expression of the B(1)R ( aortic contractility ex vivo, mRNA in hearts ) and COX2 ( immunoblots, heart extracts )
Lee et al., Arch Pharm Res 2007 : Pretreatment with apigenin also attenuated LPS induced cyclooxygenase-2 (COX-2) expression
Kim et al., Biol Pharm Bull 2007 : Inhibition of LPS induced iNOS, COX-2 and cytokines expression by poncirin through the NF-kappaB inactivation in RAW 264.7 macrophage cells
Eun et al., The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2007 : LPS induced IL-8, COX-2 , TLR-4 mRNA expression, and IL-8 protein secretion in HT-29 cells
Lee et al., J Immunol 2008 : Specifically in response to TNF-alpha, TGF-beta, and LPS , protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed
Kim et al., Eur J Pharmacol 2008 : Consistent with these findings, ILG reduced the LPS induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels in a concentration dependent manner, as determined by Western blotting and RT-PCR, respectively
Zhou et al., Eur J Pharmacol 2008 (Edema) : The results demonstrated that 4-methoxyhonokiol significantly inhibited LPS induced NO production as well as the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
Liu et al., FEBS Lett 2008 (Shock, Septic) : In the present study, we found that PTS2 dose-dependently inhibited the LPS induced up-regulation of nitric oxide synthase ( iNOS ) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells
Adams et al., Dig Dis Sci 2009 (Drug-Induced Liver Injury) : In fasted rats, LPS significantly increased serum aminotransferase levels, enhanced hepatic COX2 , iNOS, and HO1 immunoreactivity, and increased serum cytokine levels when compared to controls
Dawes et al., Am J Vet Res 2008 : Effects of lactoferrin on LPS induced gene expression of cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 were monitored by use of PCR assays
Martins et al., Cell Physiol Biochem 2008 : In the present study, we investigated the effect of insulin on the LPS induced production of nitric oxide ( NO ) and prostaglandin ( PG ) -E ( 2 ), on the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 , and on nuclear factor kappa B (NF-kappaB) activation in AMs
Kwon et al., J Mol Med (Berl) 2008 (Inflammation...) : Our in vitro experiments showed that LicA suppressed not only the generation of nitric oxide ( NO ) and prostaglandin ( PG ) E ( 2 ), but also the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells
Yun et al., J Agric Food Chem 2008 (Edema) : Consistent with these findings, sinapic acid inhibited LPS induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygase (COX)-2 at the protein levels, and iNOS, COX-2, TNF-alpha, and IL-1beta mRNA expression in RAW 264.7 macrophages, as determined by Western blotting and reverse transcribed polymerase chain reaction, respectively
Lee et al., J Microbiol Biotechnol 2008 : Lactobacillus casei 3260 ( L. casei 3260 ) was evaluated in relation to the inflammatory response mediated by lipopolysaccharide (LPS) induced nuclear factor-kappaB (NF-kappaB) and cyclooxygenase-2 (COX-2) expression in Raw264.7 macrophage cells
Luo et al., Mol Immunol 2009 (Acute Lung Injury...) : Here we show that LPS induced up-regulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW246.7 cells is significantly reduced by incubating cells with recombinant GSTP1 protein
Wang et al., Hepatology 2008 (Hepatoblastoma...) : In vivo, compared with wild-type controls, FXR ( -/- ) mice displayed elevated messenger RNA ( mRNA ) levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) , interferon-inducible protein 10, and interferon-gamma in response to lipopolysaccharide (LPS)
Choi et al., Br J Pharmacol 2009 (MAP Kinase Signaling System) : Torilin significantly reduced the LPS induced expression of iNOS, COX-2 and IL-1beta, and the subsequent release of NO, prostaglandin E ( 2 ) and IL-1beta into culture medium ... This study indicates that torilin inhibited LPS induced iNOS, COX-2 and IL-1beta via down-regulation of ERK1/2, p38 MAPK, NF-kappaB and CREB and suggests that torilin has a potential as an anti-inflammatory drug candidate
Zhou et al., J Agric Food Chem 2009 : Trifolirhizin not only dose-dependently inhibited LPS induced expression of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) but also inhibited lipopolysaccharide (LPS) induced expression of cyclooxygenase-2 (COX-2)
Jung et al., J Agric Food Chem 2009 : The results showed that dieckol suppresses LPS induced production of nitric oxide ( NO ) and prostaglandin E ( 2 ) ( PGE ( 2 ) ) and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose dependent manner, without causing cytotoxicity
Sánchez-Lemus et al., Brain Behav Immun 2009 (Inflammation) : The ARB reduced LPS induced pituitary gene expression of IL-6, LIF, iNOS, COX-2 and IkappaB-alpha ; and prevented LPS induced increase of nNOS/eNOS activity
Kim et al., Biol Pharm Bull 2009 : Fraxinellone was found to inhibit LPS induced nitric oxide ( NO ) and prostaglandin E ( 2 ) ( PGE ( 2 ) ) production, and to reduce the LPS induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the mRNA and protein levels in a dose dependent manner
Ichikawa et al., J Ethnopharmacol 2009 (MAP Kinase Signaling System) : American ginseng inhibited LPS induced iNOS expression ; however, it did not affect LPS induced COX2 expression
Lin et al., J Agric Food Chem 2009 : Moreover, FKB strongly suppressed LPS induced iNOS, COX-2 , and NF-kappaB proteins expression in mouse liver
Lee et al., J Mol Med (Berl) 2009 (Edema...) : Consistent with these findings, BITC inhibited the LPS induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 proteins and their corresponding mRNAs
Yang et al., J Neuroimmunol 2009 : We found that Brevicompanine E ( BE ), isolated from a deep ocean sediment derived fungus Penicillium sp., inhibited lipopolysaccharide (LPS) induced tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide ( iNOS ) and cyclooxygenase-2 (COX-2) production in microglia
Lee et al., BMB Rep 2009 (Inflammation) : In this study, we examined the effects of the Agrocybe chaxingu beta-glucan ( polysaccharide ) on lipopolysaccaride (LPS) induced nitric oxide ( NO ) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate ( TPA ) -induced ear edema in mice
Dambrova et al., Int Immunopharmacol 2010 (Encephalitis) : ME10092 dose-dependently inhibited LPS induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
Yasuda et al., Tohoku J Exp Med 2010 (Arthritis, Rheumatoid) : Anti-CD44 antibody reversed the inhibitory effects of HA on the LPS mediated increase in PGE ( 2 ) production, COX-2 induction, and activation of NF-kappaB
Jung et al., Int Immunopharmacol 2010 : The effect of curcumin relative to LPS is not limited to the above, as it also enhances LPS induced expression of cyclooxygenase (COX)-2 and production of prostaglandin E2 ( PGE2 )
Matsui et al., Anesth Analg 2010 : Spinal microglia isolated from Sprague-Dawley neonatal rats were cultured with lipopolysaccharide (LPS) or substance P ( SP ) alone, with LPS in combination with SP, and with LPS in the presence of each inhibitor of cyclooxygenase (COX) , NO synthase 2 (NOS2) or p38 mitogen activated protein kinase ( p38 ), or minocycline for 24 hours and 48 hours
Uto et al., Am J Chin Med 2010 : Consistent with these observations, EFE reduced the LPS induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at both protein and mRNA levels
Wang et al., Mol Pharm 2010 (Inflammation) : Quantitative real-time PCR ( qPCR ) analyses showed that LPS potently induced cyclooxygenase-2 (COX-2) , inducible nitric oxide synthase (iNOS), interleukin-1 beta ( IL-1ß ), interleukin-6 (IL-6), and tumor necrosis factor-alpha ( TNF-a ) in the macrophages collected from Nrf2 ( +/+ ) wild-type mice
Kim et al., Molecules (Basel, Switzerland) 2010 (Colitis...) : Additionally, chrysophanol inhibited the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and the expression of cyclooxygenase (COX)-2 levels induced by LPS
Fang et al., J Pharm Pharmacol 2011 : The fractions inhibited LPS induced nitric oxide production and cyclooxygenase-2 (COX-2) expression in the cells
Masferrer et al., J Clin Invest 1990 : Dexamethasone injected simultaneously with LPS, 12 h before killing of the animal and removal of the macrophages, completely blocked the LPS induced increase COX activity in peritoneal macrophages
An et al., Int Immunopharmacol 2011 : Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS induced iNOS, COX-2 , and TNF-a expression through inactivation of the nuclear factor-?b pathway in RAW 264.7 macrophages
Hsu et al., J Agric Food Chem 2011 (Laryngeal Neoplasms) : Our studies revealed that AK and MA may decrease lipopolysaccharide (LPS) induced inflammatory responses, including nitrite productions and expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in RAW 264.7 cells
Kuo et al., J Agric Food Chem 2011 : Both the SC-CO ( 2 ) extract and CA markedly suppressed the LPS induced production of nitric oxide ( NO ) and tumor necrosis factor-a (TNF-a), as well as the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) , phosphorylated inhibitor-kappaB ( P-I?B ), and nuclear factor-kappaB ( NF-?B ) /p65 in a dose dependent manner
Jedinak et al., Anticancer Res 2011 : These data were supported by the down-regulation of the LPS dependent expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) genes in the RAW264.7 cells
Lin et al., Br J Pharmacol 2011 : BACKGROUND AND PURPOSE Lipopolysaccharide (LPS) induced expression of cyclooxygenase-2 (COX-2) and cytosolic phospholipase A ( 2 ) ( cPLA(2) ) has been implicated in several respiratory diseases
Kim et al., Phytother Res 2011 (Inflammation) : The OD inhibited the enhanced levels of cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) induced by LPS
Yi et al., Zhonghua Yan Ke Za Zhi 2011 (Graves Disease...) : LPS can induce inflammatory response of orbital preadipocytes in TAO and enhance the expression of COX2 , PPAR? and PGE ( 2 )
Pettersen et al., J Virol 2011 (Chronic Disease...) : cAMP may be induced by prostaglandin E ( 2 ) following lipopolysaccharide (LPS) induced upregulation of cyclooxygenase type 2 (COX-2) in monocytes due to the elevated LPS levels in patients with chronic HIV infection
Dai et al., PloS one 2011 (MAP Kinase Signaling System) : Gastrodin significantly reduced the LPS induced protein and mRNA expression levels of iNOS, COX-2 , TNF-a, IL-1ß and NF-?B
Chanput et al., Food Funct 2010 : LPS stimulation induced inflammation related cytokine, COX-2 and NF-?B genes of THP-1 monocytes and THP-1 macrophages with the maximum up-regulation at 3 and 6 h, respectively
Yu et al., J Ethnopharmacol 2011 (Disease Models, Animal...) : Pa-EE strongly down-regulated LPS induced mRNA expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2
Hu et al., Pharmacol Rep 2011 : The protein and mRNA levels of lipopolysaccharide (LPS) induced iNOS, COX-2 and CRP were determined in RAW246.7 macrophage cells ... The results indicated that puerarin inhibited the expression of LPS induced iNOS, COX-2 and CRP proteins and also suppressed their mRNAs from RT-PCR experiments in RAW264.7 cells ... These data suggested that the effect of puerarin mediated inhibition of LPS induced iNOS, COX-2 and CRP expression is attributed to suppressed NF-?B activation at the transcriptional level
Hsu et al., Biochim Biophys Acta 2011 : In the present study, we explored the actions of trichostatin A (TSA), a potent HDAC inhibitor, on lipopolysaccharide (LPS) induced cyclooxygenase (COX)-2 expression in human umbilical vascular endothelial cells ( HUVECs )
Valente et al., Neurobiol Aging 2012 (Amyotrophic Lateral Sclerosis...) : In this study we demonstrate that the expression of nitric oxide ( NO ) synthase-2 ( NOS2 ), and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) with interferon-? is higher in microglial enriched cultures from G93A-SOD1 mice, an ALS animal model, than from wild type mice
Bae et al., Molecules (Basel, Switzerland) 2011 (Breast Neoplasms) : They also inhibited inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA expression induced by LPS
Lima Trajano et al., Inhal Toxicol 2011 (Acute Lung Injury...) : NAC also inhibited the transcription of NF?B, IL-6, TNF-a and COX2 usually induced by LPS
Qureshi et al., Lipids in health and disease 2011 (Inflammation...) : The microarray DNA analyses, followed by pathway analyses indicated that quercetin or d-tocotrienol inhibit several LPS induced expression of several ageing and pro-inflammatory genes ( IL-1ß, IL-1a, IL-6, TNF-a, IL-12, iNOS, VCAM1, ICAM1, COX2 , IL-1RA, TRAF1 and CD40 )
Kim et al., Arch Pharm Res 2011 : Astragalin significantly reduced LPS induced expression of iNOS, COX-2 and cytokines/chemokines, and production of NO in J774A.1 mouse macrophages
Chung et al., Pharmacognosy magazine 2011 : Additionally, COX-2 induced by LPS was dramatically inhibited by the Cinnamomi cortex extract
Bauerfeld et al., J Immunol 2012 : PI3K/AKT pathway inhibitors abrogated LPS mediated T-fam and COX induction
Verma et al., Journal of complementary & integrative medicine 2012 : These anti-inflammatory effects were due to an inhibitory action of SBE on LPS induced iNOS, COX-2 , TNF-a, IL-1ß, and IL-12 mRNA expressions
Xia et al., J Pineal Res 2012 (Inflammation) : In addition, melatonin significantly attenuated LPS induced upregulation of cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) in macrophages
Hsu et al., Planta Med 2012 (MAP Kinase Signaling System) : Furthermore, 2 decreased lipopolysaccharide (LPS) mediated induction of protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in RAW 264.7 cells
McElroy et al., PloS one 2012 : However, LPS also induces cyclooxygenase-2 (COX-2) , which promotes intestinal barrier restitution through stimulation of intestinal cell survival, proliferation, and migration
Su et al., Int Immunopharmacol 2012 : It also inhibited LPS induced release of nitric oxide ( NO ) and prostaglandin E2 ( PGE2 ) in serum and RAW264.7 murine macrophages and expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)
Yu et al., Evidence-based complementary and alternative medicine : eCAM 2012 : Consistent with these findings, oleifolioside A was further shown to suppress the expression of LPS stimulated inducible nitric oxide synthase (iNOS) and cyclooxigenase-2 (COX-2) in a dose dependent manner at both the protein and mRNA levels and to significantly inhibit the DNA binding activity and transcriptional activity of NF-?B in response to LPS
Zong et al., PloS one 2012 (MAP Kinase Signaling System) : Resveratrol significantly attenuated the LPS induced expression of nitric oxide ( NO ), prostaglandin E2 ( PGE2 ), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) , tumor necrosis factor-a (TNF-a) and interleukin-1ß (IL-1ß) in RAW 264.7 cells
Kang et al., Food Chem Toxicol 2012 (MAP Kinase Signaling System) : A specific NF-?B inhibitor, pyrrolidine dithiocarbamate ( PDTC ), attenuated the LPS induced expression of iNOS, COX-2 and TNF-a genes
Gutiérrez-Venegas et al., Mol Biol Rep 2013 (Chronic Periodontitis) : We studied the role of the flavonoids fisetin, luteolin, myricetin, and morin in inhibiting the activation of mitogen activated protein kinase ( MAPK ) and AKT as well as their role in lipopolysaccharide (LPS) induced cyclooxygenase-2 (COX-2) transcription
Lee et al., J Med Food 2012 (Inflammation) : Western blotting and reverse transcription-polymerase chain reaction analysis demonstrated that these sulfur compounds attenuated the LPS induced expression of the inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA
Mathew et al., Int Immunopharmacol 2013 (Arthritis...) : DHFO inhibited lipopolysaccharide (LPS) induced pro-inflammatory mediator release ( ROS, NO, IL-6 levels ) and COX2 expression in RAW264.7 murine macrophages
Yu et al., J Med Food 2013 (Inflammation) : Moreover, HAD-B significantly inhibited LPS induced mRNA expression of inducible NO synthase and cyclooxygenase (COX)-2
Kang et al., Toxicol In Vitro 2013 (MAP Kinase Signaling System) : We showed that NF-?B inhibitor N-acetyl-L-cysteine (NAC) effectively attenuates the expression of LPS stimulated iNOS, COX-2 and TNF-a
Romano et al., Br J Pharmacol 2013 : LPS induced anandamide, iNOS, COX-2 and cannabinoid receptor changes were not significantly modified by cannabichromene, which, however, increased oleoylethanolamide levels
Terazawa et al., Pharmacol Res 2013 : In BV2 microglial cells, compound 1 strongly inhibited LPS stimulated iNOS induction and NO production, but did not affect LPS stimulated induction of COX2
Li et al., Zhong Nan Da Xue Xue Bao Yi Xue Ban 2013 : To observe the expression of progesterone receptor (PR), interleukin-1ß (IL-1ß), and cyclooxygenase-2 (COX-2) induced by lipopolysaccharide (LPS) or Toll-like receptor 4 antagonist ( TLR4 mAb ) in decidual cells in vitro, and then to explore the effect of LPS and its antagonist on PR of decidual cells and the relation between PR and inflammatory cytokines
Chiao et al., Clin Sci (Lond) 2013 : LPS induced plasma levels of IL-1ß, TNFa ( tumour necrosis factor a ), IL-10, vascular eNOS ( endothelial NOS ) and COX2 ( cyclo-oxygenase 2 ) protein expression, as determined by ELISA and Western blot, observed in WT mice were inhibited by IL1ra and in P2X7KO mice
Hu et al., Cell Biol Int 2013 : Porphyromonas gingivalis lipopolysaccharide (LPS) induces the expression of the cyclooxygenase-2 (COX-2) , which contributes to the process of periodontitis
Xu et al., Int Immunopharmacol 2013 (Shock, Septic) : LPS induced expression of cyclooxygenase-2 (COX-2) was also significantly attenuated by ETH
An et al., Mol Med Report 2013 : LPS treatment significantly induced the expression of transforming growth factor a ( TNFa ) and cyclooxygenase-2 (COX-2) in rats, while C. obtusa essential oil inhibited this effect
Okuyama et al., International journal of molecular sciences 2013 : When oenothein B was administered per os ( p.o. ), it suppressed ( 1 ) LPS induced abnormal behavior in open field ; ( 2 ) LPS induced microglial activation in the hippocampus and striatum ; and ( 3 ) LPS induced cyclooxygenase (COX)-2 production in the hippocampus and striatum of these mice
Lee et al., Evidence-based complementary and alternative medicine : eCAM 2013 : The LPS induced mRNA level of iNOS, COX-2 , IL-1 ß, and TNF- a was reduced by the acute treatment with glucosylceramide in adult mice
Johnson et al., Bioorg Med Chem 2013 : Compound 2 reduced the LPS induced NO production, phosphorylation of I?Ba, and the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) using Western blot analysis
Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2013 : Compound 4 suppressed the generation of prostaglandin ( PG ) E2 and the expression of inducible NO synthase and cyclooxygenase (COX)-2 induced by LPS , and inhibited the release of LPS induced pro-inflammatory cytokines from RAW264.7 cells
Tordjman et al., Biochim Biophys Acta 1995 : The COX2 expression was amplified by arachidonic acid cascade stimulating agents ( Ca, Mg, zymosan ) and by LPS in a time-dependant manner ; PGE2 by itself amplified LPS induced COX2 expression
Barrios-Rodiles et al., Biochem Biophys Res Commun 1996 : Furthermore, COX-2 mRNA levels induced by LPS were transient ( peak 3-4 h ), suggesting that PGE2 was unable to regulate COX-2 expression in an autocrine manner
Fujiwara et al., FEBS Lett 1996 : These compounds also prevented LPS stimulated heme oxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) gene expression in RAW264.7 cells, but again not in VSMC
Niiro et al., Blood 1997 : Moreover, IL-10 and IL-4 inhibited LPS induced cyclooxygenase (COX) activity in neutrophils
Moon et al., Cell Immunol 1998 : LPS , although showing minimal effects, significantly augmented the c-kit ligand (KL)- or IgE dependent expression of cyclooxygenase (COX)-2 and the attendant delayed PGD2 generation, with IL-10 and IL-4 acting as potentiating and inhibitory cytokines, respectively
Endo et al., Am J Respir Cell Mol Biol 1998 : Lipopolysaccharide (LPS) stimulated PGE2 synthesis and COX activity were suppressed significantly by IL-4, but were not affected significantly by IL-10, IL-13, or IFN-gamma ... The LPS dependent increase in COX activity in AM was attributable to COX-2 because it was inhibited by NS-398 ( a COX-2-specific inhibitor )
Quan et al., Brain Res 1998 : These results suggest that peripheral LPS induces a rapid increase in COX 2 production throughout the vasculatures of the brain, which could affect the neuronal activity of widespread brain regions by elevating the levels of prostaglandins