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KDR — RHOA

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: RHOA → KDR (increases, KDR Activity, RHOA Activity) Zeng et al., J Biol Chem 2003*
  Evidence: Our most recent works show that pertussis toxin-sensitive G proteins and Gbetagamma subunits are required for Flt-1-mediated down-regulation of human umbilical vein endothelial cell (HUVEC) proliferation and that Gq/11 proteins are required for KDR-mediated RhoA activation and HUVEC migration.
• NCI Pathway Database Integrins in angiogenesis: Hsp90 (HSP90AA1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: ROCK (ROCK1) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) (modification, collaborate)
  Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → RhoA (RHOA) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Integrins in angiogenesis: VEGFR2 homodimer/VEGFA homodimer complex (KDR-VEGFA) → RhoA (RHOA) (modification, collaborate) Soldi et al., EMBO J 1999, Le Boeuf et al., J Biol Chem 2004, Le Boeuf et al., Mol Biol Cell 2006
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by VEGFR1 and VEGFR2: RHOA/GDP complex (RHOA) → VEGFR2 (dimer)/VEGFA (dimer)/Hsp90/alphav/beta3 Integrin/Vitronectin complex (KDR-VEGFA-HSP90AA1-VTN-ITGAV-ITGB3) (modification, collaborate)
  Le Boeuf et al., J Biol Chem 2004
  Evidence: mutant phenotype
• NCI Pathway Database Integrins in angiogenesis: VEGF/Rho/ROCK/alphav/beta3 Integrin complex (KDR-VEGFA-HSP90AA1-RHOA-ROCK1-ITGAV-ITGB3) → FAK (PTK2) (modification, activates) Le Boeuf et al., Mol Biol Cell 2006, Abedi et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: RHOA → KDR (reaction) Le Boeuf et al., Mol Biol Cell 2006

Text-mined interactions from Literome

Gingras et al., Biochem J 2000 : Transient overexpression of a dominant-active RhoA mutant also induced an increase in the tyrosine phosphorylation of the VEGFR-2 , whereas overexpression of a dominant-inactive form of the protein was without effect
Zeng et al., J Biol Chem 2003 : Our most recent works show that pertussis toxin-sensitive G proteins and Gbetagamma subunits are required for Flt-1 mediated down-regulation of human umbilical vein endothelial cell ( HUVEC ) proliferation and that Gq/11 proteins are required for KDR mediated RhoA activation and HUVEC migration
Sivaraj et al., Dev Cell 2013 (Neovascularization, Pathologic) : G13 mediated VEGFR-2 expression involved activation of the small GTPase RhoA and transcription factor NF-?B, the latter acting via a specific binding site at position -84 of the VEGFR-2 promoter