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IL10 — PTGS2
Text-mined interactions from Literome
Alaaeddine et al., Arthritis Rheum 1999
(Osteoarthritis) :
IL-4,
IL-10 , and IL-13
reduced the TNFalpha induced
COX-2 level, and IL-4 and IL-10 reduced the cPLA2 level
Fosslien et al., Ann Clin Lab Sci 2000
(Carcinoma, Squamous Cell...) :
COX-2 is
inducible by oncogenes ras and scr,
interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha
Nédélec et al., Biochem Pharmacol 2001
:
In monolayers,
interleukin-1beta (IL-1beta)
induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Moore et al., J Appl Physiol 2001
:
In human cultured airway smooth muscle cells,
interleukin (IL)-1 beta
increases cyclooxygenase
(COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Harizi et al., J Immunol 2002
:
We found that exogenous
IL-10 inhibits IL-12p70 production in the presence of NS-398, a
COX-2 selective
inhibitor , while the inhibitory effects of PGE ( 2 ) were totally reversed by anti-IL-10
Nagano et al., Int Immunol 2002
:
Since we previously showed that
IL-10 and IL-4 similarly
inhibited COX-2 expression in LPS stimulated neutrophils, we next tested the effects of IL-10 and IL-4 on the phosphorylation and activation of both kinases
Heuze-Vourc'h et al., Cancer Res 2003
(Carcinoma, Non-Small-Cell Lung...) :
Western blotting and ELISA analyses revealed that
IL-10 did not
affect COX-2 expression and subsequent PGE ( 2 ) production in NSCLC cells
Soloff et al., Endocrinology 2004
:
In situ analysis of
interleukin-1 induced transcription of
cox-2 and il-8 in cultured human myometrial cells
Inoue et al., J Immunol 2004
(MAP Kinase Signaling System) :
Both
IL-10 and IL-4 significantly
inhibited PGE ( 2 ) production and
COX-2 expression in CD40 stimulated monocytes
Harizi et al., Cell Immunol 2004
:
Exogenous
IL-10 , but not IL-6, dose-dependently
suppresses COX-2 protein expression and PGE ( 2 ) production, and TNF-alpha does not reverse this effect
Stamp et al., J Rheumatol 2004
:
Paracrine upregulation of monocyte
cyclooxygenase-2 by mediators produced by T lymphocytes :
role of
interleukin 17 and interferon-gamma
Payvandi et al., Cell Immunol 2004
:
Immunomodulatory drugs inhibit expression of
cyclooxygenase-2 from TNF-alpha, IL-1beta, and LPS stimulated human PBMC in a partially
IL-10 dependent manner
Shibata et al., J Leukoc Biol 2005
:
To assess whether
IL-10 regulates PGE2 biosynthesis and
PGHS-2 expression, splenic and bone marrow MO were isolated from IL-10-deficient ( IL-10 ( -/- ) ), C57Bl/6 [ wild-type ( WT ) control ], and Balb/c ( comparison control ) mice and were treated with lipopolysaccharide (LPS) and/or interferon-gamma (IFN-gamma) as a model of bacterial inflammation
Ha et al., J Leukoc Biol 2005
:
Inhibition of
cyclooxygenase 2 significantly
reduced the PSG17N mediated increase in
IL-10 and IL-6
Attar et al., Hum Reprod Update 2006
(Endometriosis...) :
COX-2 in turn is
stimulated by E ( 2 ),
interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Hanna et al., Am J Reprod Immunol 2006
(Chorioamnionitis...) :
Evidence for
interleukin-10 mediated inhibition of
cyclo- oxygenase-2 expression and prostaglandin production in preterm human placenta ... Here we examined the expression profiles of
IL-10 and cyclo-oxygenase-2 (COX-2), and the
effect of IL-10 on
COX-2 expression and prostaglandin release in the human placenta from preterm labor deliveries associated with chorioamnionitis ... Importantly,
IL-10 inhibited
COX-2 expression in cultured placental explants from preterm labor deliveries, but not from term labor samples
Wu et al., Prostaglandins Other Lipid Mediat 2007
:
In this review, we provide evidence for reduced
COX-2 transcriptional expression in
response to phorbol esters ( PMA ), lipopolysaccharide (LPS),
interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007
(Endometriosis) :
These results, along with recent findings that TSA suppresses proliferation,
interleukin-1 beta
induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
Lima-Rodrigues et al., Laryngoscope 2008
(Disease Models, Animal...) :
In regard to mRNA expression levels of inflammatory mediators, TNF-[alpha ] was increased during the 5 week NGI, and
IL-10 decreased during the 5 weeks, whereas IL-1[beta ], IL-6, and
COX-2 increased in the first 1 to 2 weeks and returned to baseline at 5 weeks
Vinukonda et al., Brain 2010
(Disease Models, Animal...) :
Cyclooxygenase-2 or prostanoid receptor-1 inhibition
reduced tumour necrosis factor-a level, but not
interleukin-1ß
Patel et al., J Cell Mol Med 2012
(Carcinoma, Non-Small-Cell Lung...) :
IL-10 production in non-small cell lung carcinoma patients is
regulated by ERK, P38 and
COX-2
Martín et al., J Hypertens 2012
:
PPAR? activation with pioglitazone reduces
interleukin-1ß induced
COX-2 expression by interference with the redox-sensitive transcription factor NF-?B ... This study analyzes the effect of pioglitazone, a PPAR? agonist, on
interleukin-1ß induced
COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect
Seo et al., Immunopharmacol Immunotoxicol 2012
(Inflammation) :
SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ),
interleukin-6 , and tumor necrosis factor-a and
inhibited the expression of iNOS and
COX-2 via attenuation of NF-?B p65 expression
Obermajer et al., Transplantation research 2012
:
We observed that PGE2 induces endogenous cyclooxygenase
(COX)2 expression in cultured monocytes, blocking their differentiation into CD1a+ dendritic cells (DCs) and
inducing the expression of indoleamine 2,3-dioxygenase 1, IL-4Ra, nitric oxide synthase 2 and
IL-10 - typical MDSC associated suppressive factors
MacKenzie et al., Mol Cell Biol 2013
:
This was found to be the result of an interleukin 10 (IL-10) feedback mechanism, with endogenously produced
IL-10 promoting
cox-2 degradation
Niiro et al., Blood 1995
:
IL-10 and IL-4 significantly
inhibited LPS induced
COX-2 expression
Mertz et al., J Biol Chem 1994
:
The decrease in prostaglandin production was primarily related to the
effect of
IL-10 on
PGHS-2 , since the release of arachidonic acid was unaffected by this cytokine
Szczepanski et al., Arthritis Rheum 1994
:
Induction of
cyclooxygenase II in human synovial microvessel endothelial cells by
interleukin-1
Feng et al., Arch Biochem Biophys 1993
:
In rat vascular smooth muscle cells,
interleukin-1 beta selectively
increased the expression of
COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Bingham et al., J Biol Chem 1996
:
BALB/cJ mouse bone marrow derived mast cells ( BMMC ) developed with interleukin (IL)-3 can be stimulated by c-kit ligand (KL) in the
presence of
IL-10 and IL-1beta for sequential immediate and delayed generation of prostaglandin ( PG ) D2 through utilization of constitutive prostaglandin endoperoxide synthase ( PGHS) -1 and induced
PGHS-2 , respectively ( Murakami, M., Matsumoto, R., Austen, K. F., and Arm, J. P. ( 1994 ) J. Biol. Chem. 269, 22269-22275 )
Crofford et al., Arthritis Rheum 1997
(Arthritis, Rheumatoid) :
Involvement of nuclear factor kappa B in the
regulation of
cyclooxygenase-2 expression by
interleukin-1 in rheumatoid synoviocytes
Niiro et al., Blood 1997
:
Regulation by
interleukin-10 and interleukin-4 of
cyclooxygenase-2 expression in human neutrophils
Kniss et al., Am J Obstet Gynecol 1997
:
Interleukin-1 receptor antagonist blocks
interleukin-1 induced expression of
cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress
interleukin-1 induced
cyclooxygenase-2 expression
Staels et al., Nature 1998
(Coronary Disease...) :
In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit
interleukin-1 induced production of interleukin-6 and prostaglandin and expression of
cyclooxygenase-2
Endo et al., Am J Respir Cell Mol Biol 1998
:
IL-4,
IL-10 , and IL-13 significantly
suppressed LPS dependent PGE2 synthesis and
COX-2 mRNA induction in monocytes, whereas only IL-4 significantly suppressed them in AM
Niiro et al., Biochem Biophys Res Commun 1998
:
Since we previously showed that
interleukin (IL)-10 and IL-4 similarly
inhibited COX-2 expression in LPS stimulated monocytes, we next questioned whether these cytokines regulate the phosphorylation and activation of ERK2 and p38 MAPK in LPS stimulated monocytes
Longo et al., Mediators Inflamm 1998
:
The
role of cyclooxygenase-1 and
cyclooxygenase-2 in lipopolysaccharide and
interleukin-1 stimulated enterocyte prostanoid formation