Miyazaki et al., Ann Hematol 2001
:
Requirement of thrombopoietin induced activation of ERK for megakaryocyte differentiation and of p38 for erythroid differentiation
Kamata et al., Blood 2004
(Thrombocytopenia) :
Moreover, raf-1 ( -/- ) megakaryocytes do not have a compensatory increase in A-Raf or B-Raf expression, and thrombopoietin induced ERK1/2 phosphorylation is similar in raf-1 ( -/- ) and raf-1 ( +/+ ) megakaryocytes ... These unexpected findings demonstrate that Raf-1 is dispensable for megakaryocytopoiesis, and for thrombopoietin induced ERK1/2 activation in primary megakaryocyte-lineage cells
Samoylenko et al., Cell Signal 2008
:
Thrombopoietin inhibits nerve growth factor induced neuronal differentiation and ERK signalling