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IL4 — PRG2
Text-mined interactions from Literome
Lubberts et al., Arthritis Rheum 2000
:
Reduction of
interleukin-17 induced inhibition of chondrocyte
proteoglycan synthesis in intact murine articular cartilage by interleukin-4
Dudler et al., Ann Rheum Dis 2000
(Arthritis) :
Effect of
interleukin 17 on
proteoglycan degradation in murine knee joints
Hashimoto-Uoshima et al., J Periodontal Res 2002
(Gingivitis) :
Effects of
interleukin-4 on
proteoglycan accumulation in human gingival fibroblasts
Henderson et al., Cytokine 1991
(Synovitis) :
Inhibition of
interleukin-1 induced synovitis and articular cartilage
proteoglycan loss in the rabbit knee by recombinant human interleukin-1 receptor antagonist
Kandel et al., J Rheumatol 1990
:
Comparison of the
effect of interleukin 6 and
interleukin 1 on collagenase and
proteoglycan production by chondrocytes
Heino et al., Biochem J 1988
:
Human recombinant
interleukin-1 regulates cellular mRNA levels of dermatan sulphate
proteoglycan core protein
Bocquet et al., Biochem Biophys Res Commun 1986
:
Effect of a
interleukin-1 like factor ( mononuclear cell factor ) on
proteoglycan synthesis in cultured human articular chondrocytes
Ratcliffe et al., Biochem J 1986
:
Characterization of the proteoglycans in the media after 1.5 days and 3 days of culture showed that
interleukin 1
promoted the release of
proteoglycan of large average size and also the release of link protein and of low-Mr binding region which was unattached to proteoglycan
Wegrowski et al., Biochem J 1995
:
Here we report the
effects of recombinant human
IL-4 on glycosaminoglycan ( GAG ) and
proteoglycan synthesis in normal dermal fibroblasts from adult donors
Panthou et al., Biochem Mol Biol Int 1994
:
Effects of transforming growth factor-beta 1,
interleukin-1 alpha and interleukin-6 on rat Sertoli cell
proteoglycan synthesis
Yeh et al., J Rheumatol 1995
:
To determine the ability of
interleukin-4 (IL-4) to
inhibit the degradation of
proteoglycan in bovine articular cartilage explants stimulated by human interleukin-1 ( IL-1 alpha ), tumor necrosis factor ( TNF-alpha ), a combination of TNF-alpha and IL-1 alpha, and lipopolysaccharide (LPS) ...
IL-4 significantly
reduced the cartilage
proteoglycan degradation induced by IL-1 alpha, TNF-alpha, TNF-alpha plus IL-1 alpha, or LPS ( 50 % inhibitory concentration, IC50 for IL-4 ranged from about 15 to 50 ng/ml )
Platt et al., Equine Vet J 1994
:
An investigation of the
proteoglycan metabolism of mature equine articular cartilage and its
regulation by
interleukin-1