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BMP2 — SHH

Text-mined interactions from Literome

Liem et al., Development 2000 : Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites
Ohkubo et al., Neuroscience 2002 (Abnormalities, Drug-Induced...) : Similarly, loss of SHH expression in Shh mutant mice leads to increased BMP signaling and loss of Fgf8 expression in the prosencephalon
Zhang et al., Development 2002 (Cleft Palate) : Further in vitro assays indicated that Shh ( normally expressed in the MEE ) activates Bmp2 expression in the palatal mesenchyme which in turn acts as a mitogen to stimulate cell division
Harris et al., J Exp Zool 2002 : We show that Shh signaling is necessary for the formation and proper differentiation of a barb ridge and that it is mediated by Bmp signaling ... BMP signaling is necessary and sufficient to negatively regulate Shh expression within forming feather germs and this epistatic relationship is conserved in scale morphogenesis
Anderson et al., Development 2002 (Craniofacial Abnormalities...) : Ectopic application of BMP2 to wild-type cephalic explants results in decreased FGF8 and SHH expression in rostral tissue, suggesting that the decreased expression of FGF8 and SHH observed in vivo is due to ectopic BMP activity
Zhao et al., Mol Cell Biol 2006 : Finally, Sonic hedgehog (Shh) stimulates BMP-2 promoter activity and osteoblast differentiation, and the effects of Shh are mediated by Gli2
Foppiano et al., Dev Biol 2007 : Additionally, adding exogenous SHH into the mesenchyme of RCAS-Noggin infected embryos did not restore Bmp2 and Bmp4 to a normal pattern of expression
Lan et al., Development 2009 : Furthermore, we show that Shh signaling regulates Bmp2 , Bmp4 and Fgf10 expression in the developing palatal mesenchyme and that specific inactivation of Smo in the palatal mesenchyme indirectly affects palatal epithelial cell proliferation
Sharov et al., Am J Pathol 2009 (Cell Transformation, Neoplastic...) : Furthermore, BMP signaling stimulated Wnt inhibitory factor-1 expression and promoter activity in cultured tumor cells and HaCaT keratinocytes, as well as inhibited Shh expression, as compared with the corresponding controls
Huang et al., J Bone Miner Res 2010 : At the molecular level, Smad4 mediated TGF-beta/BMP signaling is required for Shh expression in HERS and Nfic ( nuclear factor Ic ) expression in the cranial neural crest (CNC) derived dental mesenchyme
Guimond et al., BMC developmental biology 2010 : Since BMP-2 expression is on the anterior portion of developing and regenerating limbs prior to digit patterning, opposite to the expression of sonic hedgehog, we examined whether BMP-2 expression was dependent on sonic hedgehog signaling and whether it affects patterning of the autopod during regeneration ... The inhibition of sonic hedgehog signaling with cyclopamine caused hypomorphic limbs ( during development and regeneration ) but did not affect the expression of BMP-2 and SOX-9 ... The expression of BMP-2 and its target SOX-9 was independent of sonic hedgehog signaling in developing and regenerating limbs
Nishimori et al., J Biol Chem 2012 (Bone Neoplasms...) : In human prostate cancer LNCaP cells, BMP-4 induced the production of Sonic hedgehog (SHH) through a Smad dependent pathway
Hofmann et al., Dev Genet 1996 (Congenital Abnormalities...) : Here we show that Hoxd-11 expression domains are also contracted and decreased in intensity in mutant limbs, suggesting that 5 ' genes of the Hoxd cluster are coordinately downregulated, while another Bmp , Bmp-2, which can be activated by Shh , is similarly expressed
Yang et al., Development 1997 : However, Shh induces dose dependent expression of Bmp genes in anterior mesenchyme at the start of the promotion phase